Synthesis of novel metalloporphyrins and their action on the growth metabolism of E-coli

Based on 5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin (2), a series of water insoluble and water-soluble metalloporphyrins has been synthesized. An LKB-2277 thermal activity monitor was used to monitor the cell metabolic activity in vitro to produce thermogenesis curves. The growth rate constants k, maximum heat production rates p(max) and peak time of growth thermogenic curves t of E. coli in different metalloporphyrins at different concentrations were deduced from these thermogenesis curves. Metalloporphyrins 4a similar to 4f and 7a similar to 7f show inhibiting action on the growth metabolism of E. coli with water-soluble metalloporphyrins 7a similar to 7f being the better ones.