Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

被引：41

作者：

Bukh, Jens ^{[1
,2
,3
,4
]}

Engle, Ronald E. ^{[4
]}

Faulk, Kristina ^{[4
]}

Wang, Richard Y. ^{[5
]}

Farci, Patrizia ^{[4
]}

Alter, Harvey J. ^{[5
]}

Purcell, Robert H. ^{[4
]}

机构：

[1] Univ Copenhagen, Dept Infect Dis, Copenhagen Hepatitis Program CO HEP C, Copenhagen, Denmark

[2] Univ Copenhagen, Hvidovre Hosp, Clin Res Ctr, Copenhagen, Denmark

[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Immunol & Microbiol, Copenhagen, Denmark

[4] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[5] NIH, Warren Grant Magnuson Clin Ctr, Dept Transfus Med, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 17期

关键词：

CELL-CULTURE SYSTEMS; MOLECULAR CLONE; GENOTYPE; 5A; INFECTION; VACCINE; LIVER; GLYCOPROTEIN; PREVENTION; ASSAY; HCV;

D O I：

10.1128/JVI.01194-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.

引用

页码：9128 / 9132

页数：5

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