Hydrogen Sulfide Alleviates Skeletal Muscle Fibrosis via Attenuating Inflammation and Oxidative Stress

被引：34

作者：

Zhao, Linlin ^{[1
]}

Liu, Xiaoguang ^{[1
]}

Zhang, Jing ^{[1
]}

Dong, Gaoyang ^{[1
]}

Xiao, Weihua ^{[1
]}

Xu, Xin ^{[1
]}

机构：

[1] Shanghai Univ Sport, Sch Kinesiol, Shanghai, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

skeletal muscle; contusion; inflammation; fibrosis; hydrogen sulfide; MATRIX METALLOPROTEINASES; DIABETIC-RATS; INJURY; REGENERATION; MIGRATION; PROTECTS; IMPROVE; REPAIR;

D O I：

10.3389/fphys.2020.533690

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The purpose of this study was to investigate the effect of exogenous hydrogen sulfide (H2S) treatment on skeletal muscle contusion. We established a skeletal muscle contusion model (S group) and an H2S treated of skeletal muscle contusion model (H2S group). Gastrocnemius muscles (GMs) were collected at day 1, day 5, day 10, and day 15 after injury, and comprehensive morphological and genetic analyses was conducted. H2S treatment reduced M1 macrophage (CD68), profibrotic cytokines (TGF-beta), pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-1 beta, and IL-6), chemokines (CCL2, CCR2, CCL3, CCL5, CXCL12, and CXCR4), matrix metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-14) and oxidative stress factor (gp91phox) expression levels, improved M2 macrophage (CD206) level. Thus, exogenous H2S treatment reduced inflammation and oxidative stress, attenuated skeletal muscle fibrosis, and partly improved skeletal muscle injury.

引用

页数：11

共 41 条

[31] Mechanisms of Muscle Injury, Repair, and Regeneration [J].

Tidball, James G. .

COMPREHENSIVE PHYSIOLOGY, 2011, 1 (04) :2029-2062

[32] Role of hydrogen sulfide in skeletal muscle biology and metabolism [J].

Veeranki, Sudhakar ;

Tyagi, Suresh C. .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2015, 46 :66-71

[33] Light-emitting diode therapy increases collagen deposition during the repair process of skeletal muscle [J].

Viana de Melo, Claudia Aparecida ;

Alves, Agnelo Neves ;

Lins Terena, Stella Maris ;

Santos Fernandes, Kristianne Porta ;

Nunes, Fabio Daumas ;

Teixeira da Silva, Daniela de Fatima ;

Bussadori, Sandra Kalil ;

Deana, Alessandro Melo ;

Mesquita-Ferrari, Raquel Agnelli .

LASERS IN MEDICAL SCIENCE, 2016, 31 (03) :531-538

[34] Endogenous CSE/Hydrogen Sulfide System Regulates the Effects of Glucocorticoids and Insulin on Muscle Protein Synthesis [J].

Wang, Ruxia ;

Li, Kelin ;

Wang, Hui ;

Jiao, Hongchao ;

Wang, Xiaojuan ;

Zhao, Jingpeng ;

Lin, Hai .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 2019

[35] Treatment of muscle injuries by local administration of autologous conditioned serum: Animal experiments using a muscle contusion model [J].

Wright-Carpenter, T ;

Opolon, P ;

Appell, HJ ;

Meijer, H ;

Wehling, P ;

Mir, LM .

INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2004, 25 (08) :582-587

[36] Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters [J].

Xiao, Ting ;

Zeng, Ou ;

Luo, Jian ;

Wu, Zhixiong ;

Li, Fang ;

Yang, Jun .

BIO-MEDICAL MATERIALS AND ENGINEERING, 2015, 26 :S2033-S2039

[37] Macrophage Depletion Impairs Skeletal Muscle Regeneration: the Roles of Pro-fibrotic Factors, Inflammation, and Oxidative Stress [J].

Xiao, Weihua ;

Liu, Yu ;

Chen, Peijie .

INFLAMMATION, 2016, 39 (06) :2016-2028

[38] Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Cytotoxicity and Inflammation in HaCaT Cells through Inhibition of ROS/NF-κB/COX-2 Pathway [J].

Yang, Chuntao ;

Yang, Zhanli ;

Zhang, Meifen ;

Dong, Qi ;

Wang, Xiuyu ;

Lan, Aiping ;

Zeng, Fanqin ;

Chen, Peixi ;

Wang, Chuhuai ;

Feng, Jianqiang .

PLOS ONE, 2011, 6 (07)

[39] Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats [J].

Yin, Jun ;

Tu, Chao ;

Zhao, Jie ;

Ou, Danmin ;

Chen, Guangwen ;

Liu, Ying ;

Xiao, Xianzhong .

BRAIN RESEARCH, 2013, 1491 :188-196

[40] Hydrogen Sulfide Inhibits the Development of Atherosclerosis with Suppressing CX3CR1 and CX3CL1 Expression [J].

Zhang, Huili ;

Guo, Changfa ;

Wu, Duojiao ;

Zhang, Alian ;

Gu, Ting ;

Wang, Liansheng ;

Wang, Changqian .

PLOS ONE, 2012, 7 (07)

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