Hydrogen Sulfide Alleviates Skeletal Muscle Fibrosis via Attenuating Inflammation and Oxidative Stress

被引：29
作者：
Zhao, Linlin [1 ]
Liu, Xiaoguang [1 ]
Zhang, Jing [1 ]
Dong, Gaoyang [1 ]
Xiao, Weihua [1 ]
Xu, Xin [1 ]
机构：
[1] Shanghai Univ Sport, Sch Kinesiol, Shanghai, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷
基金：
中国国家自然科学基金;
关键词：
skeletal muscle; contusion; inflammation; fibrosis; hydrogen sulfide; MATRIX METALLOPROTEINASES; DIABETIC-RATS; INJURY; REGENERATION; MIGRATION; PROTECTS; IMPROVE; REPAIR;
D O I：
10.3389/fphys.2020.533690
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The purpose of this study was to investigate the effect of exogenous hydrogen sulfide (H2S) treatment on skeletal muscle contusion. We established a skeletal muscle contusion model (S group) and an H2S treated of skeletal muscle contusion model (H2S group). Gastrocnemius muscles (GMs) were collected at day 1, day 5, day 10, and day 15 after injury, and comprehensive morphological and genetic analyses was conducted. H2S treatment reduced M1 macrophage (CD68), profibrotic cytokines (TGF-beta), pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-1 beta, and IL-6), chemokines (CCL2, CCR2, CCL3, CCL5, CXCL12, and CXCR4), matrix metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-14) and oxidative stress factor (gp91phox) expression levels, improved M2 macrophage (CD206) level. Thus, exogenous H2S treatment reduced inflammation and oxidative stress, attenuated skeletal muscle fibrosis, and partly improved skeletal muscle injury.
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页数：11
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