Cardiac reprogramming: from mouse toward man

被引：8

作者：

Srivastava, Deepak ^{[1
,2
,3
,4
]}

Berry, Emily C. ^{[1
,2
,3
,4
]}

机构：

[1] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Roddenberry Ctr Stem Cell Biol & Med, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2013年 / 23卷 / 05期

基金：

美国国家科学基金会;

关键词：

DIRECT CONVERSION; HUMAN FIBROBLASTS; ENDOTHELIAL-CELLS; REPAIR;

D O I：

10.1016/j.gde.2013.07.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Loss of cardiomyocytes from cardiovascular disease is irreversible and current therapeutic strategies do not redress the loss of myocardium after injury. The discovery that endogenous fibroblasts in the heart can be reprogrammed to cardiomyocyte-like cells after myocardial infarction and heart function is improved subsequently has strong implications in bringing this treatment paradigm to the clinic. Here we discuss the advances in direct cardiac reprogramming that will potentially act as a springboard in the generation of effective approaches to restoring cardiac function after injury.

引用

页码：574 / 578

页数：5

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