Maternal MTHFR polymorphisms and risk of spontaneous abortion

被引：0

作者：

del Rosario Rodriguez-Guillen, Maria ^{[1
]}

Torres-Sanchez, Luisa ^{[1
]}

Chen, Jia ^{[2
,3
,4
]}

Galvan-Portillo, Marcia ^{[1
]}

Blanco-Munoz, Julia ^{[1
]}

Aracely Anaya, Miriam ^{[5
]}

Silva-Zolezzi, Irma ^{[6
]}

Hernandez-Valero, Maria A. ^{[7
]}

Lopez-Carrillo, Lizbeth ^{[1
]}

机构：

[1] Natl Inst Publ Hlth, Cuernavaca 62508, Morelos, Mexico

[2] Mt Sinai Sch Med, Dept Community & Prevent Med, New York, NY USA

[3] Mt Sinai Sch Med, Dept Pediat, New York, NY USA

[4] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY USA

[5] Univ Autonoma Estado Queretaro, Escuela Nutr, Fac Ciencias Nat, Queretaro, Mexico

[6] Mexican Inst Genom Med, Mexico City, DF, Mexico

[7] Univ Texas MD Anderson Canc Ctr, Ctr Res Minor Hlth, Dept Hlth Dispar Res, Houston, TX 77030 USA

来源：

SALUD PUBLICA DE MEXICO | 2009年 / 51卷 / 01期

关键词：

MTHFR; 677 C > T and 1298A > C polymorphisms; spontaneous abortion; Mexico; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; NEURAL-TUBE DEFECTS; FACTOR-V-LEIDEN; DNA HYPOMETHYLATION; COMMON MUTATION; PREGNANCY LOSS; GENE; FREQUENCY; MEXICO; WOMEN;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective. To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). Material and Methods. We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire, Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC. Results, Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (OR 677TT vs. CC/CT=5.0; 95% Cl: 1.2, 20.9 and OR 1298 AC vs. AA=5.5; 95% Cl: 1.1, 26.6). Conclusions. Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins.

引用

页码：19 / 25

页数：7

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