共 29 条
Human endothelial cells express NOD2/CRD15 and increase IL-6 secretion in response to muramyl dipeptide
被引:54
作者:

Davey, MP
论文数: 0 引用数: 0
h-index: 0
机构: Dept Vet Affairs Med Ctr, Portland, OR 97239 USA

Martin, TM
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h-index: 0
机构: Dept Vet Affairs Med Ctr, Portland, OR 97239 USA

Planck, SR
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h-index: 0
机构: Dept Vet Affairs Med Ctr, Portland, OR 97239 USA

Lee, J
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h-index: 0
机构: Dept Vet Affairs Med Ctr, Portland, OR 97239 USA

Zamora, D
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h-index: 0
机构: Dept Vet Affairs Med Ctr, Portland, OR 97239 USA

Rosenbaum, JT
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h-index: 0
机构: Dept Vet Affairs Med Ctr, Portland, OR 97239 USA
机构:
[1] Dept Vet Affairs Med Ctr, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97239 USA
[3] Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97239 USA
[4] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97239 USA
[5] Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97239 USA
关键词:
NOD2;
gene;
endothelial cells;
gene expression;
muramyl dipeptide;
interleukin-6;
Blau syndrome;
D O I:
10.1016/j.mvr.2005.11.010
中图分类号:
R6 [外科学];
学科分类号:
1002 ;
100210 ;
摘要:
Mutations in the human NOD2/CARD15 gene cause Blau syndrome, an auto inflammatory disorder involving the joints, skin and eyes. Insights into the mechanism of this association may be gained by a further understanding of where NOD2 is expressed. The objective of this study was to analyze ocular endothelial cells for NOD2 expression. Human ocular tissue was analyzed by immunohistology using anti-NOD2 antisera. RNA isolated from iris, choroid and endothelial cell lines was analyzed by reverse transcription-PCR and real-time quantitative PCR. Gene regulation was studied by treating endothelial cells with TNF-alpha and IFN-gamma. Functional responses were assessed by measuring IL-6 release from endothelial cells treated with muramyl dipeptide (MDP), synthetic lipopeptide (Pam3CSK4) and lipopolysaccharide (LPS). Immunohistological analysis revealed staining of endothelial cells in the uveal tract. NOD2 expression was detected in primary ocular endothelial cell cultures, and levels increased in response to inflammatory cytokines. Endothelial cells from choroid demonstrated enhanced release of IL-6 in response to MDP, and synergy was observed following treatment with MDP and either Pam3CSK4 or LPS. The observations that endothelial cells express NOD2, upregulate NOD2 in response to stimuli known to promote NOD2 expression and show synergistic cytokine responses to MDP and TLR ligands previously shown to be mediated by NOD2 are informative since they may be relevant to pathogenic mechanisms leading to the spectrum of inflammation seen in Blau syndrome. (c) 2005 Elsevier Inc. All rights reserved.
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页码:103 / 107
页数:5
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