Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P)

被引：2

作者：

Li, Yunpan ^{[1
,2
,3
]}

Ibanez, David P. ^{[1
,2
,3
,4
]}

Fan, Wenxia ^{[5
]}

Zhao, Ping ^{[6
]}

Chen, Shuhan ^{[1
,2
,3
,4
]}

Abdul, Mazid Md ^{[1
,2
,3
]}

Jiang, Yu ^{[1
,2
,3
]}

Fu, Lixin ^{[1
,2
,3
,4
]}

Luo, Zhiwei ^{[5
]}

Liu, Zhenhua ^{[7
,8
]}

Yang, Yueli ^{[9
]}

Guo, Jifeng ^{[7
,8
]}

Volpe, Giacomo ^{[1
,2
,3
]}

Kanwal, Shahzina ^{[1
,2
,3
]}

Wang, Dongye ^{[1
,2
,3
]}

Tang, Beisha ^{[7
,8
]}

Li, Wenjuan ^{[1
,2
,3
,5
]}

机构：

[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Integrat Biol, Guangzhou 510530, Peoples R China

[2] Key Lab Regenerat Biol, Guangzhou 510530, Peoples R China

[3] Guangdong Prov Key Lab Stem Cells & Regenerat Med, Guangzhou 510530, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Guangzhou Med Univ, Guangzhou 511436, Peoples R China

[6] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510005, Peoples R China

[7] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China

[8] Cent South Univ, Natl Clin Res Ctr Geriatr Dis, Changsha 410008, Peoples R China

[9] Jilin Univ, Coll Vet Med, Changchun 130062, Peoples R China

来源：

STEM CELL RESEARCH | 2020年 / 46卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

DJ-1;

D O I：

10.1016/j.scr.2020.101845

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mutations occurring in the gene body of PARK7 (encoding DJ-1/PARK7) cause autosomal recessive early-onset parkinsonism (AREP). These mutations produce a loss of function and have been reported to lead to dopaminergic neuron degeneration in the substantia nigra. However, the underlying mechanisms are largely unknown. Here, we report the generation of a patient-derived induced pluripotent stem cell (iPSC) line carrying mutant DJ-1 (p.L10P). This cell line is a valuable tool for in vitro Parkinson's disease (PD) modeling and mechanistic studies.

引用

页数：5

共 4 条

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