Therapeutic strategies for intracerebral hemorrhage

被引：32

作者：

Li, Zhe ^{[1
,2
,3
]}

Khan, Suliman ^{[1
,2
,3
]}

Liu, Yang ^{[1
,2
,3
]}

Wei, Ruixue ^{[1
,2
,3
]}

Yong, V. Wee ^{[4
]}

Xue, Mengzhou ^{[1
,2
,3
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China

[3] Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R China

[4] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB, Canada

来源：

FRONTIERS IN NEUROLOGY | 2022年 / 13卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

intracerebral hemorrhage; secondary brain injury; therapeutic strategies; neuroinflammation; neuronal death; DELAYED POSTISCHEMIC HYPOTHERMIA; INITIAL CONSERVATIVE TREATMENT; MINIMALLY INVASIVE SURGERY; ACUTE CEREBRAL-HEMORRHAGE; ACTIVATED FACTOR-VII; BRAIN-INJURY; PLATELET TRANSFUSION; ACUTE STROKE; CELL-DEATH; OPEN-LABEL;

D O I：

10.3389/fneur.2022.1032343

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stroke is the second highest cause of death globally, with an increasing incidence in developing countries. Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes. ICH is associated with poor neurological outcomes and high mortality due to the combination of primary and secondary injury. Fortunately, experimental therapies are available that may improve functional outcomes in patients with ICH. These therapies targeting secondary brain injury have attracted substantial attention in their translational potential. Here, we summarize recent advances in therapeutic strategies and directions for ICH and discuss the barriers and issues that need to be overcome to improve ICH prognosis.

引用

页数：13

共 148 条

[91] Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury [J].