Reassessing the role of astrocytes in ammonia neurotoxicity

被引：7

作者：

Eid, Tore ^{[1
,2
]}

Lee, Tih-Shih W. ^{[3
]}

机构：

[1] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 12期

关键词：

GLUTAMINE; SEIZURES;

D O I：

10.1038/nm.3420

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High blood ammonia, as seen in severe liver disease and urea cycle disorders, is neurotoxic and difficult to treat. A new study shows that the toxic effects are caused by impaired astrocyte potassium buffering—not astrocyte swelling, as previously thought—and can be partially blocked by the diuretic bumetanide (pages 1643–1648). © 2013 Nature America, Inc. All rights reserved.

引用

收藏

页码：1572 / 1574

页数：3

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