Reassessing the role of astrocytes in ammonia neurotoxicity

被引：7
作者：
Eid, Tore [1 ,2 ]
Lee, Tih-Shih W. [3 ]
机构：
[1] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06510 USA
[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
来源：
NATURE MEDICINE | 2013年 / 19卷 / 12期
关键词：
GLUTAMINE; SEIZURES;
D O I：
10.1038/nm.3420
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
High blood ammonia, as seen in severe liver disease and urea cycle disorders, is neurotoxic and difficult to treat. A new study shows that the toxic effects are caused by impaired astrocyte potassium buffering—not astrocyte swelling, as previously thought—and can be partially blocked by the diuretic bumetanide (pages 1643–1648). © 2013 Nature America, Inc. All rights reserved.
引用
收藏
页码：1572 / 1574
页数：3
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