Peripheral venous thrombosis in children and adolescents with adipsic hypernatremia secondary to hypothalamic tumors

Objective: To determine the clinical presentation and laboratory follow-up in patients with the syndrome of adipsic hypernatremia complicated with a peripheral thrombosis event. Methods: Report of 3 patients ( 6 - 19 years old) with chronic hypernatremia with sustained difficulties to normalize their serum osmolality levels. Results: During post-surgical management the 3 patients developed a peripheral venous thrombotic event as a complication of their chronic hyperosmolality. Conclusions: Chronic hypernatremia in patients with prolonged immobilization is associated with an increased risk for development of deep venous thrombosis. Copyright (C) 2004 S. Karger AG, Basel.