Metabonomic approaches to nutrient metabolism and future molecular nutrition

被引：14
作者：
Rezzi, Serge [1 ]
Collino, Sebastian [1 ]
Goulet, Laurence [1 ]
Martin, Francois-Pierre [1 ]
机构：
[1] Nestle Inst Hlth Sci SA, CH-1015 Lausanne, Switzerland
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2013年 / 52卷
关键词：
Biomarker; Metabonomics; Metabolomics; Micronutrient; Nutrient; Nutritional phenotype; Omics; Stratified nutrient requirements; System biology; Targeted nutrition; FATTY-LIVER-DISEASE; ALZHEIMER-DISEASE; PLATELET ACTIVATION; SYSTEMS BIOLOGY; GUT MICROBIOTA; METABOLOMICS; OBESE; DIET; RISK; NMR;
D O I：
10.1016/j.trac.2013.09.004
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Metabonomics provides access to the environmental, diet, genetic and metagenetic integrative metabolic phenotype of individuals. Recent advances in spectroscopic and chromatographic techniques can capture metabolites and nutrients within a broad dynamic range. Applications to nutrition sciences have addressed nutrient metabolism and diet-related phenotypes under healthy and pathological conditions. Future molecular stratified nutrition requires development of comprehensive, quantitative profiling of nutrients to match the individual's specific requirements and metabolic peculiarities (metabolic phenotype) to improve health and dietary management of medical conditions. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：112 / 119
页数：8
相关论文
共 70 条
  • [11] Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic, and Clinical Implications
    Fabbrini, Elisa
    Sullivan, Shelby
    Klein, Samuel
    [J]. HEPATOLOGY, 2010, 51 (02) : 679 - 689
  • [12] Fanos V, 2013, EARLY HUM DEV, V89, pS7, DOI 10.1016/S0378-3782(13)70003-3
  • [13] URINARY METABOLOMICS IN NEWBORNS AND INFANTS
    Fanos, Vassilios
    Antonucci, Roberto
    Barberini, Luigi
    Atzori, Luigi
    [J]. ADVANCES IN CLINICAL CHEMISTRY, VOL 58, 2012, 58 : 193 - +
  • [14] Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women
    Fiehn, Oliver
    Garvey, W. Timothy
    Newman, John W.
    Lok, Kerry H.
    Hoppel, Charles L.
    Adams, Sean H.
    [J]. PLOS ONE, 2010, 5 (12): : 1 - 10
  • [15] Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
    Floegel, Anna
    Stefan, Norbert
    Yu, Zhonghao
    Muehlenbruch, Kristin
    Drogan, Dagmar
    Joost, Hans-Georg
    Fritsche, Andreas
    Haering, Hans-Ulrich
    de Angelis, Martin Hrabe
    Peters, Annette
    Roden, Michael
    Prehn, Cornelia
    Wang-Sattler, Rui
    Illig, Thomas
    Schulze, Matthias B.
    Adamski, Jerzy
    Boeing, Heiner
    Pischon, Tobias
    [J]. DIABETES, 2013, 62 (02) : 639 - 648
  • [16] ω-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease:: OmegAD study -: A randomized double-blind trial
    Freund-Levi, Yvonne
    Eriksdotter-Jonhagen, Maria
    Cederholm, Tommy
    Basun, Hans
    Faxen-Irving, Gerd
    Garlind, Anita
    Vedin, Inger
    Vessby, Bengt
    Wahlund, Lars-Olof
    Palmblad, Jan
    [J]. ARCHIVES OF NEUROLOGY, 2006, 63 (10) : 1402 - +
  • [17] Isotopomics: A Top-Down Systems Biology Approach for Understanding Dynamic Metabolism in Rats Using [1,2-13C2] Acetate
    Godin, Jean-Philippe
    Ross, Alastair B.
    Rezzi, Serge
    Poussin, Carine
    Martin, Francois-Pierre
    Fuerholz, Andreas
    Cleroux, Marilyn
    Mermoud, Anne-France
    Tornier, Lionel
    Vera, Francia Arce
    Pouteau, Etienne
    Ramadan, Ziad
    Kochhar, Sunil
    Fay, Laurent-Bernard
    [J]. ANALYTICAL CHEMISTRY, 2010, 82 (02) : 646 - 653
  • [18] Stability and Robustness of Human Metabolic Phenotypes in Response to Sequential Food Challenges
    Heinzmann, Silke S.
    Merrifield, Claire A.
    Rezzi, Serge
    Kochhar, Sunil
    Lindon, John C.
    Holmes, Elaine
    Nicholson, Jeremy K.
    [J]. JOURNAL OF PROTEOME RESEARCH, 2012, 11 (02) : 643 - 655
  • [19] Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption
    Heinzmann, Silke S.
    Brown, Ian J.
    Chan, Queenie
    Bictash, Magda
    Dumas, Marc-Emmanuel
    Kochhar, Sunil
    Stamler, Jeremiah
    Holmes, Elaine
    Elliott, Paul
    Nicholson, Jeremy K.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 92 (02) : 436 - 443
  • [20] Synthesis of fat in response to alterations in diet: Insights from new stable isotope methodologies
    Hellerstein, MK
    [J]. LIPIDS, 1996, 31 : S117 - S125
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