Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

被引：3

作者：

Zhao, Dan ^{[1
]}

Liu, Huayong ^{[2
,3
,4
]}

Zheng, Likang ^{[1
]}

He, Guozhen ^{[1
]}

Qu, Di ^{[2
,3
,4
]}

Han, Shiqing ^{[1
]}

机构：

[1] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 210009, Peoples R China

[2] Fudan Univ, Minist Educ, Key Lab Med Mol Virol, Shanghai 200032, Peoples R China

[3] Fudan Univ, Minist Publ Hlth, Inst Med Microbiol, Shanghai 200032, Peoples R China

[4] Fudan Univ, Shanghai Med Sch, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 08期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

4-Thiazolidione; Methicillin-resistant Staphylococcus epidermidis; Methicillin-resistant Staphylococcus aureus; Antibacterial activity; 2-COMPONENT; VANCOMYCIN;

D O I：

10.1007/s00044-012-0363-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h-k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57-3.13 mu M). Further antibacterial effects of compounds (7d, 7h-k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.

引用

页码：3743 / 3750

页数：8

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