Rh(III)-catalyzed chelation-assisted intermolecular carbenoid functionalization of α-imino Csp3-H bonds

被引：42

作者：

Chen, Xun ^{[1
]}

Xie, Ying ^{[1
]}

Xiao, Xinsheng ^{[1
]}

Li, Guoqiang ^{[2
]}

Deng, Yuanfu ^{[1
]}

Jiang, Huanfeng ^{[1
]}

Zeng, Wei ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510641, Guangdong, Peoples R China

[2] Jinan Univ, Anal & Testing Ctr, Guangzhou 510632, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 83期

关键词：

C-H FUNCTIONALIZATION; INSERTION REACTIONS; ONE-POT; CYCLIZATION; ALKYNES; CYCLOPROPANATION; DIAZOOXINDOLES; KETOIMINES; ALDEHYDES; ACCESS;

D O I：

10.1039/c5cc06428g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Rh(III)-catalyzed cross-coupling/cyclization cascade of alpha-imino Csp(3)-H bonds with donor/acceptor alpha-acyl diazocarbonyl compounds has been developed. This novel transformation involves ligand-directed Csp(3)-H bond functionalization with carbenoids under the pyridine-chelation assistance, and offered an efficient access to synthetically versatile polysubstituted N-(2-pyridyl)pyrroles with a broad range of functional group tolerance.

引用

页码：15328 / 15331

页数：4

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