microRNA exchange via extracellular vesicles in cancer

被引：43
作者：
Vu, Luyen Tien [1 ,2 ]
Gong, Jinhua [2 ,3 ]
Pham, Thach Tuan [1 ,2 ]
Kim, Yeokyeong [2 ]
Le, Minh T. N. [1 ,2 ,3 ]
机构：
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore
[2] City Univ Hong Kong, Dept Biomed Sci, Coll Vet Med & Life Sci, Kowloon, Hong Kong, Peoples R China
[3] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
来源：
CELL PROLIFERATION | 2020年 / 53卷 / 11期
基金：
中国国家自然科学基金;
关键词：
cancer biology; extracellular vesicles; microRNAs; tumour microenvironment; DENDRITIC CELLS; PROMOTES ANGIOGENESIS; CIRCULATING MICRORNAS; MEDIATED TRANSFER; MESSENGER-RNAS; ANNEXIN A2; T-CELLS; EXOSOMES; EXPRESSION; MECHANISM;
D O I：
10.1111/cpr.12877
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cells utilize different means of inter-cellular communication to function properly. Here, we review the crosstalk between cancer cells and their surrounding environment through microRNA (miRNA)-containing extracellular vesicles (EVs). The current findings suggest that the export of miRNAs and uptake of miRNA-containing EVs might be an active process. As post-transcriptional regulators of gene expression, cancer-derived miRNAs that are taken up by normal cells can change the translational profile of the recipient cell towards a transformed proteome. Stromal cells can also deliver miRNAs via EVs to cancer cells to support tumour growth and cancer progression. Therefore, gaining a better understanding of EV-mediated inter-cellular communication in the tumour microenvironment might lead to the development of novel diagnostic and therapeutic strategies.
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页数：11
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