microRNA exchange via extracellular vesicles in cancer

被引：46

作者：

Vu, Luyen Tien ^{[1
,2
]}

Gong, Jinhua ^{[2
,3
]}

Pham, Thach Tuan ^{[1
,2
]}

Kim, Yeokyeong ^{[2
]}

Le, Minh T. N. ^{[1
,2
,3
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore

[2] City Univ Hong Kong, Dept Biomed Sci, Coll Vet Med & Life Sci, Kowloon, Hong Kong, Peoples R China

[3] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China

来源：

CELL PROLIFERATION | 2020年 / 53卷 / 11期

基金：

中国国家自然科学基金;

关键词：

cancer biology; extracellular vesicles; microRNAs; tumour microenvironment; DENDRITIC CELLS; PROMOTES ANGIOGENESIS; CIRCULATING MICRORNAS; MEDIATED TRANSFER; MESSENGER-RNAS; ANNEXIN A2; T-CELLS; EXOSOMES; EXPRESSION; MECHANISM;

D O I：

10.1111/cpr.12877

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells utilize different means of inter-cellular communication to function properly. Here, we review the crosstalk between cancer cells and their surrounding environment through microRNA (miRNA)-containing extracellular vesicles (EVs). The current findings suggest that the export of miRNAs and uptake of miRNA-containing EVs might be an active process. As post-transcriptional regulators of gene expression, cancer-derived miRNAs that are taken up by normal cells can change the translational profile of the recipient cell towards a transformed proteome. Stromal cells can also deliver miRNAs via EVs to cancer cells to support tumour growth and cancer progression. Therefore, gaining a better understanding of EV-mediated inter-cellular communication in the tumour microenvironment might lead to the development of novel diagnostic and therapeutic strategies.

引用

页数：11

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