Therapeutic Potential of Regulatory T cells in Autoimmune Disorders

被引：23

作者：

Fessler, Johannes ^{[1
]}

Felber, Anja ^{[1
]}

Duftner, Christina ^{[2
]}

Dejaco, Christian ^{[1
]}

机构：

[1] Med Univ Graz, Dept Rheumatol & Immunol, A-8036 Graz, Austria

[2] Gen Hosp Kufstein, Dept Internal Med, Kufstein, Austria

来源：

BIODRUGS | 2013年 / 27卷 / 04期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS; FOXP3; EXPRESSION; CUTTING EDGE; TGF-BETA; COMBINATION THERAPY; ADOPTIVE TRANSFER; PERIPHERAL-BLOOD; SELF-TOLERANCE;

D O I：

10.1007/s40259-013-0026-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Regulatory T cells (Tregs) play a dominant role in the regulation of immune responses. Quantitative and/or qualitative abnormalities of Tregs were observed in patients with autoimmune diseases and therapeutic interventions focusing Tregs are an attractive new target with the potential to cure these disorders. Biological agents approved for treatment of inflammatory rheumatic diseases transiently influence Treg prevalences and function and experimental therapies including novel biological agents, gene therapy, activation and ex vivo expansion of purified Tregs as well as substances influencing tolerogenic dendritic cells will be developed for selective Treg therapy. Although many of these interventions are effective in vitro, in animal models as well as in early clinical trials, significant concerns exist regarding the stability of Treg modifications as well as the long-term safety of Treg-based therapies.

引用

页码：281 / 291

页数：11

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