A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng

被引：48

作者：

Poudyal, Deepak ^{[1
]}

Cui, Xiangli ^{[1
,2
]}

Le, Phuong Mai ^{[3
]}

Hofseth, Anne B. ^{[1
]}

Windust, Anthony ^{[3
]}

Nagarkatti, Mitzi ^{[4
]}

Nagarkatti, Prakash S. ^{[4
]}

Schetter, Aaron J. ^{[5
]}

Harris, Curtis C. ^{[5
]}

Hofseth, Lorne J. ^{[1
]}

机构：

[1] Univ S Carolina, Dept Drug Discovery & Biomed Sci, South Carolina Coll Pharm, Columbia, SC 29208 USA

[2] Shanxi Med Univ, Taiyuan, Shanxi, Peoples R China

[3] Natl Res Council Canada, Inst Natl Measurement Stand, Ottawa, ON K1A 0R6, Canada

[4] Univ S Carolina, Sch Med, Columbia, SC USA

[5] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

PLOS ONE | 2013年 / 8卷 / 10期

关键词：

MATRIX METALLOPROTEINASES; GENE-EXPRESSION; COLORECTAL-CANCER; TUMOR INVASION; LUNG-CANCER; METASTASIS; MMP-9; MATRIX-METALLOPROTEINASE-7; GINSENOSIDE-RB2; PROLIFERATION;

D O I：

10.1371/journal.pone.0075034

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anticancer properties. Dysregulated microRNA (miR) expression has been observed in several disease conditions including colon cancer. Using global miR expression profiling, we observed increased miR-29b in colon cancer cells following exposure to HAG. Since miR-29b plays a role in regulating the migration of cancer cells, we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 (MMP-2) thereby suppressing the migration of colon cancer cells. Results are consistent with this hypothesis. Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells.

引用

页数：9

共 50 条

[41] Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression [J].

Zhai, Zanjing ;

Qu, Xinhua ;

Li, Haowei ;

Ouyang, Zhengxiao ;

Yan, Wei ;

Liu, Guangwang ;

Liu, Xuqiang ;

Fan, Qiming ;

Tang, Tingting ;

Dai, Kerong ;

Qin, An .

MOLECULAR MEDICINE REPORTS, 2015, 11 (02) :1139-1145

[42] Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer [J].

Tanaka, Takeshi ;

Arai, Makoto ;

Wu, Shuang ;

Kanda, Tatsuo ;

Miyauchi, Hideaki ;

Imazeki, Fumio ;

Matsubara, Hisahiro ;

Yokosuka, Osamu .

ONCOLOGY REPORTS, 2011, 26 (05) :1329-1335

[43] MicroRNA-106b targets FUT6 to promote cell migration, invasion, and proliferation in human breast cancer [J].

Li, Nana ;

Liu, Yuejian ;

Miao, Yuan ;

Zhao, Lifen ;

Zhou, Huimin ;

Jia, Li .

IUBMB LIFE, 2016, 68 (09) :764-775

[44] MiR-23b inhibits cell migration and invasion through targeting PDE7A in colon cancer cells [J].

Hao, Lingfang ;

Yu, Honggang .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (09) :9436-9443

[45] RETRACTED: MicroRNA-133a-3p inhibits cell proliferation, migration and invasion in colorectal cancer by targeting AQP1 (Retracted article. See vol. 29, 2025) [J].

Kong, Bin ;

Zhao, Shipeng ;

Kang, Xianwu ;

Wang, Bo .

ONCOLOGY LETTERS, 2021, 22 (03)

[46] MicroRNA-630 acts as a prognostic marker in gastric cancer and its role in cell migration and invasion [J].

Zhou, Lei ;

Zhang, Haifeng ;

Li, Chaofeng ;

Zhang, Guochao ;

Song, Xin ;

Liu, Jixi .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (05) :4969-4978

[47] MicroRNA-153 acts as a prognostic marker in gastric cancer and its role in cell migration and invasion [J].

Zhang, Zhengliang ;

Sun, Jiangli ;

Bai, Zhenghai ;

Li, Haijun ;

He, Shicai ;

Chen, Rui ;

Che, Xiangming .

ONCOTARGETS AND THERAPY, 2015, 8 :357-364

[48] MicroRNA 32 promotes cell proliferation, migration, and suppresses apoptosis in colon cancer cells by targeting OTU domain containing 3 [J].

Jin, Yanzhao ;

Cheng, Hua ;

Cao, Jiaqing ;

Shen, Wei .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (11) :18629-18639

[49] MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression [J].

Zhao, Aihua ;

Zeng, Quan ;

Xie, Xiaoyan ;

Zhou, Junnian ;

Yue, Wen ;

Li, Yali ;

Pei, Xuetao .

JOURNAL OF GENETICS AND GENOMICS, 2012, 39 (01) :29-35

[50] MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression [J].

Aihua Zhao~(a .

Journal of Genetics and Genomics, 2012, (01) :27-33

← 1 2 3 4 5 →