A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng

被引：48

作者：

Poudyal, Deepak ^{[1
]}

Cui, Xiangli ^{[1
,2
]}

Le, Phuong Mai ^{[3
]}

Hofseth, Anne B. ^{[1
]}

Windust, Anthony ^{[3
]}

Nagarkatti, Mitzi ^{[4
]}

Nagarkatti, Prakash S. ^{[4
]}

Schetter, Aaron J. ^{[5
]}

Harris, Curtis C. ^{[5
]}

Hofseth, Lorne J. ^{[1
]}

机构：

[1] Univ S Carolina, Dept Drug Discovery & Biomed Sci, South Carolina Coll Pharm, Columbia, SC 29208 USA

[2] Shanxi Med Univ, Taiyuan, Shanxi, Peoples R China

[3] Natl Res Council Canada, Inst Natl Measurement Stand, Ottawa, ON K1A 0R6, Canada

[4] Univ S Carolina, Sch Med, Columbia, SC USA

[5] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

PLOS ONE | 2013年 / 8卷 / 10期

关键词：

MATRIX METALLOPROTEINASES; GENE-EXPRESSION; COLORECTAL-CANCER; TUMOR INVASION; LUNG-CANCER; METASTASIS; MMP-9; MATRIX-METALLOPROTEINASE-7; GINSENOSIDE-RB2; PROLIFERATION;

D O I：

10.1371/journal.pone.0075034

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anticancer properties. Dysregulated microRNA (miR) expression has been observed in several disease conditions including colon cancer. Using global miR expression profiling, we observed increased miR-29b in colon cancer cells following exposure to HAG. Since miR-29b plays a role in regulating the migration of cancer cells, we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 (MMP-2) thereby suppressing the migration of colon cancer cells. Results are consistent with this hypothesis. Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells.

引用

页数：9

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