A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng

被引：47
|
作者：
Poudyal, Deepak [1 ]
Cui, Xiangli [1 ,2 ]
Le, Phuong Mai [3 ]
Hofseth, Anne B. [1 ]
Windust, Anthony [3 ]
Nagarkatti, Mitzi [4 ]
Nagarkatti, Prakash S. [4 ]
Schetter, Aaron J. [5 ]
Harris, Curtis C. [5 ]
Hofseth, Lorne J. [1 ]
机构：
[1] Univ S Carolina, Dept Drug Discovery & Biomed Sci, South Carolina Coll Pharm, Columbia, SC 29208 USA
[2] Shanxi Med Univ, Taiyuan, Shanxi, Peoples R China
[3] Natl Res Council Canada, Inst Natl Measurement Stand, Ottawa, ON K1A 0R6, Canada
[4] Univ S Carolina, Sch Med, Columbia, SC USA
[5] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
PLOS ONE | 2013年 / 8卷 / 10期
关键词：
MATRIX METALLOPROTEINASES; GENE-EXPRESSION; COLORECTAL-CANCER; TUMOR INVASION; LUNG-CANCER; METASTASIS; MMP-9; MATRIX-METALLOPROTEINASE-7; GINSENOSIDE-RB2; PROLIFERATION;
D O I：
10.1371/journal.pone.0075034
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anticancer properties. Dysregulated microRNA (miR) expression has been observed in several disease conditions including colon cancer. Using global miR expression profiling, we observed increased miR-29b in colon cancer cells following exposure to HAG. Since miR-29b plays a role in regulating the migration of cancer cells, we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 (MMP-2) thereby suppressing the migration of colon cancer cells. Results are consistent with this hypothesis. Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells.
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页数：9
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