Synthesis of New Quinazolin-4-(3H)-one Derivatives and Evaluation of Their Biological Activities

被引：13

作者：

Mostafavi, Hamid ^{[1
,2
]}

Islami, Mohammad Reza ^{[1
]}

Khabazzadeh, Hojatollah ^{[1
]}

Khaleghi, Moj ^{[3
]}

机构：

[1] Shahid Bahonar Univ Kerman, Dept Chem, Kerman 7616914111, Iran

[2] AREEO, Kerman Agr & Nat Resource Res & Educ Ctr, Kerman, Iran

[3] Shahid Bahonar Univ Kerman, Dept Biol, Kerman 7616914111, Iran

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 11期

关键词：

Anthranilamide; Antimicrobial properties; Azo; Cyclization; 4-(3H)-Quinazolinones; STEREOSELECTIVE-SYNTHESIS; INHIBITORS; DESIGN; POTENT;

D O I：

10.1002/slct.201803039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of quinazolin-4-ones are conveniently synthesized in a one-pot procedure from anthranilamide derivatives and aldehydes using p-toluenesulfonic acid as a catalyst. The aim of inserting azo pyridyl and 4-amino benzamide groups in the structure of quinazolin-4-one derivatives is to achieve skeletal appearance with more antibacterial and antifungal properties. Therefore, the biological activities of the synthetic compounds were studied. The results revealed that almost all compounds exhibit antimicrobial activities.

引用

页码：3169 / 3174

页数：6

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