Serinol: small molecule - big impact

被引：35

作者：

Andreessen, Bjoern ^{[1
]}

Steinbuechel, Alexander ^{[1
]}

机构：

[1] Univ Munster, Inst Mol Mikrobiol & Biotechnol, D-48149 Munster, Germany

来源：

AMB EXPRESS | 2011年 / 1卷

关键词：

2-Amino-1; 3-propanediol; Amino alcohol; Serinol; (MASKED)SERINOLS MOLECULES; BUILDING-BLOCKS; RHIZOBITOXINE; CERAMIDE; BIOMOLECULES; DERIVATIVES; EXPRESSION; APOPTOSIS; SEQUENCE; GENES;

D O I：

10.1186/2191-0855-1-12

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used for X-ray contrast agents, pharmaceuticals or for chemical sphingosine/ceramide synthesis. It can either be obtained by chemical processes based on 2-nitro-1,3-propanediol, dihydroxyacetone and ammonia, dihydroxyacetone oxime or 5-amino-1,3-dioxane, or biotechnological application of amino alcohol dehydrogenases (AMDH) or transaminases. This review provides a survey of synthesis, properties and applications for serinol.

引用

页码：1 / 6

页数：6

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