Ficolins in complement activation

被引：56
作者：
Matsushita, Misao [1 ]
机构：
[1] Tokai Univ, Dept Appl Biochem, Hiratsuka, Kanagawa 2591292, Japan
来源：
MOLECULAR IMMUNOLOGY | 2013年 / 55卷 / 01期
关键词：
Ficolin; Lectin; MASP; Complement; Innate immunity; MANNOSE-BINDING LECTIN; PATTERN-RECOGNITION MOLECULES; INNATE IMMUNE RECOGNITION; HAKATA ANTIGEN; PATHWAY ACTIVATION; PROTEIN; CLONING; MOUSE; MEMBER; GENE;
D O I：
10.1016/j.molimm.2012.08.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc). Ficolins in serum are complexed with MBL-associated serine proteases (MASPs) and their truncated proteins. These lectins play an important role in innate immunity. Binding of the ficolin-MASP complex to carbohydrates present on the surface of microbes initiates complement activation via the lectin pathway. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：22 / 26
页数：5
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