Ficolins in complement activation

被引：56

作者：

Matsushita, Misao ^{[1
]}

机构：

[1] Tokai Univ, Dept Appl Biochem, Hiratsuka, Kanagawa 2591292, Japan

来源：

MOLECULAR IMMUNOLOGY | 2013年 / 55卷 / 01期

关键词：

Ficolin; Lectin; MASP; Complement; Innate immunity; MANNOSE-BINDING LECTIN; PATTERN-RECOGNITION MOLECULES; INNATE IMMUNE RECOGNITION; HAKATA ANTIGEN; PATHWAY ACTIVATION; PROTEIN; CLONING; MOUSE; MEMBER; GENE;

D O I：

10.1016/j.molimm.2012.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc). Ficolins in serum are complexed with MBL-associated serine proteases (MASPs) and their truncated proteins. These lectins play an important role in innate immunity. Binding of the ficolin-MASP complex to carbohydrates present on the surface of microbes initiates complement activation via the lectin pathway. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：22 / 26

页数：5

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