Fatigue in motor neuron diseases

被引：22

作者：

Abraham, Alon

Drory, Vivian E. ^{[1
]}

机构：

[1] Tel Aviv Med Ctr & Sch Med, Dept Neurol, Neuromuscular Serv, IL-64239 Tel Aviv, Israel

来源：

NEUROMUSCULAR DISORDERS | 2012年 / 22卷

关键词：

Muscle fatigue; Motor neuron diseases; Amyotrophic lateral sclerosis; Post-polio syndrome; AMYOTROPHIC-LATERAL-SCLEROSIS; QUALITY-OF-LIFE; DEPRESSION; MANAGEMENT; EXERCISE; SCALE; ALS;

D O I：

10.1016/j.nmd.2012.10.013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Motor neuron diseases as amyotrophic lateral sclerosis and post-polio syndrome are characterized by prominent muscular weakness and severe motor disability. The prevalence of fatigue in motor neuron diseases is remarkably high, and may contribute significantly to patients' disability and a poor quality of life. Despite its high prevalence, fatigue is an understudied clinical problem in motor neuron diseases and is often overlooked. The present review will attempt to explain the pathogenic mechanisms of muscle fatigue in amyotrophic lateral sclerosis and post-polio syndrome, to cover the various methods of quantification of fatigue that measure both subjective and physiological components, and to summarize the evidence regarding therapeutic interventions that can be used in order to minimize this symptom. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：S198 / S202

页数：5

共 27 条

[1]

Aboussouan LS, 2001, MUSCLE NERVE, V24, P403, DOI 10.1002/1097-4598(200103)24:3<403::AID-MUS1013>3.0.CO

[2]

2-3

[3] MUSCLE PERFORMANCE, VOLUNTARY ACTIVATION AND PERCEIVED EFFORT IN NORMAL SUBJECTS AND PATIENTS WITH PRIOR POLIOMYELITIS [J].