Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis

被引：11
作者：
Bu, Qiuning [1 ,2 ]
Wang, Xiaojuan [1 ]
Wang, Ling [1 ]
Liu, Peng [1 ]
Geng, Jiabao [3 ]
Wang, Maorong [3 ]
Han, Jian [1 ]
Zhu, Yonghong [1 ]
Zhuang, Hui [1 ]
机构：
[1] Peking Univ, Ctr Infect Dis, Dept Microbiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
[2] First Hosp Qinhuangdao, Clin Lab, Qinhuangdao, Hebei Province, Peoples R China
[3] 81st Hosp PLA, Inst Hepatol, Nanjing, Jiangsu, Peoples R China
来源：
ARCHIVES OF VIROLOGY | 2013年 / 158卷 / 01期
基金：
美国国家科学基金会;
关键词：
HEV INFECTION; TRANSPLANT RECIPIENTS; ZOONOTIC TRANSMISSION; DISEASE; CHINA; SWINE; FULMINANT; DECOMPENSATION; SUPERINFECTION; FRANCE;
D O I：
10.1007/s00705-012-1488-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The full-length genome sequence of a genotype 4 strain of Hepatitis E virus (HEV) (CHN-NJ-H2011) from a patient (in Nanjing, China) with liver failure has been determined. Phylogenetic analysis showed that CHN-NJ-H2011 belongs to genotype 4, subtype 4h. Comparative sequence analysis carried out on a 301-bp fragment of ORF2 showed that CHN-NJ-H2011 shares high nucleotide sequence identity (94.3-94.7 %) with porcine viruses (ch-shsw1 and Ch-estw2) isolated in the same geographical region, pointing to the strong possibility of zoonotic transmission of HEV genotype 4. A broader comparison with other genotype 4 isolates revealed 12 unique amino acid substitutions in ORF1 and three in ORF2 that might serve as signatures of disease severity for genotype 4 HEV infection.
引用
收藏
页码：165 / 172
页数：8
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