Intestinal Mucosal Defense System, Part 2. Probiotics and Prebiotics

被引:16
作者
Murguia-Peniche, Teresa [1 ]
Mihatsch, Walter A. [2 ]
Zegarra, Jaime [3 ]
Supapannachart, Sarayut [4 ]
Ding, Zong-Yi [5 ]
Neu, Josef [6 ]
机构
[1] Natl Ctr Child & Adolescent Hlth CeNSIA, Mexico City, DF, Mexico
[2] Munich Municipal Hosp, Munich, Germany
[3] Hosp Nacl Cayetano Heredia, Lima, Peru
[4] Mahidol Univ, Sch Med, Ramathibodi Hosp, Bangkok 10700, Thailand
[5] Gen Hosp Beijing Mil Def Area, August Childrens Hosp 1, Beijing, Peoples R China
[6] Univ Florida, Gainesville, FL USA
关键词
PREVENT NECROTIZING ENTEROCOLITIS; LACTIS BB12 SUPPLEMENTATION; LACTOBACILLUS-RHAMNOSUS GG; WEIGHT PRETERM INFANTS; DOUBLE-BLIND; BIFIDOBACTERIUM-LACTIS; GASTROINTESTINAL MOTILITY; ORAL SUPPLEMENTATION; FECAL BIFIDOBACTERIA; PREMATURE-INFANTS;
D O I
10.1016/j.jpeds.2012.11.055
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The interplay between microorganisms and the intestine of newborn infants is associated with diverse functional and clinical outcomes that result from the specific interactions among microbial communities, their products, and the unique characteristics of the gastrointestinal tract. Multiple mechanisms of action for infant formula ingredients with probiotic activity appear to exist. These mechanisms are thought to protect the host not only from intestinal diseases but also from systemic infection. However, questions about the safety of probiotics for preterm infants remain unanswered, particularly with regard to sepsis, immunomodulatory effects, and microbial resistance. Few well-designed studies have been conducted to evaluate the effects of probiotic, prebiotic, and synbiotic ingredients on relevant clinical outcomes in preterm infants. Although existing data are encouraging, there is insufficient evidence to recommend the routine use of these ingredients in all preterm infants. (J Pediatr 2013;162:S64-71).
引用
收藏
页码:S64 / S71
页数:8
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