Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans

被引：151
|
作者：
Wang, Joshua L. [1 ,2 ]
Lim, Andrew S. [1 ,2 ,3 ]
Chiang, Wei-Yin [4 ,5 ]
Hsieh, Wan-Hsin [4 ,5 ]
Lo, Men-Tzung [4 ,5 ]
Schneider, Julie A. [6 ]
Buchman, Aron S. [6 ]
Bennett, David A. [6 ]
Hu, Kun [1 ,2 ,4 ,5 ]
Saper, Clifford B. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Neurol, Program Neurosci,Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Neurol, Div Sleep Med,Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[3] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med, Div Neurol, Toronto, ON, Canada
[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Med Biodynam Program,Div Sleep Med, Boston, MA 02115 USA
[5] Natl Cent Univ, Ctr Dynam Biomarkers & Translat Med, Chungli 32054, Taiwan
[6] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA
来源：
ANNALS OF NEUROLOGY | 2015年 / 78卷 / 02期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
BRIGHT LIGHT TREATMENT; ALZHEIMERS-DISEASE; NUCLEUS; DEMENTIA; CLOCK; SLEEP; BRAIN; SCN; SEX; AGE;
D O I：
10.1002/ana.24432
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day-night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age-matched controls is correlated with the number of vasoactive intestinal peptide-expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging- and AD-related circadian disturbances. Ann Neurol 2015;78:317-322
引用
收藏
页码：317 / 322
页数：6
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