LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity

被引：118
作者：
Fabisiak, Adam [1 ,2 ]
Murawska, Natalia [1 ,2 ]
Fichna, Jakub [1 ]
机构：
[1] Med Univ Lodz, Dept Biochem, Fac Med, Lodz, Poland
[2] Med Univ Lodz, Dept Pathol, Fac Med, Lodz, Poland
来源：
PHARMACOLOGICAL REPORTS | 2016年 / 68卷 / 04期
关键词：
Cathelicidin; LL-37; Antimicrobial peptide; OBSTRUCTIVE PULMONARY-DISEASE; NEUTROPHIL EXTRACELLULAR TRAPS; INFLAMMATORY BOWEL DISEASES; CONTROLLED CLINICAL-TRIAL; ALPHA-HELICAL PEPTIDES; AIRWAY SURFACE FLUID; ATOPIC-DERMATITIS; HUMAN MACROPHAGES; CYSTIC-FIBROSIS; IN-VIVO;
D O I：
10.1016/j.pharep.2016.03.015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Antimicrobial peptides (AMPs) is a large family of compounds serving as natural antibiotics, widely distributed across the organism, mainly in mucus layers. They are designed to prevent pathogens from colonization. Among them, defensins and cathelicidins could be found. LL-37, the sole human cathelicidin draws particular attention because of its outstanding abilities. In addition to being a broad spectrum antibiotic, LL-37 has potent chemotactic and immunomodulatory properties. In this review, we discussed the potency of LL-37 as a therapeutic agent in four systems: immunological, respiratory, gastrointestinal and in the skin. We analyzed the main molecular pathways dependent on human cathelicidin and related them to specific diseases. We conclude that LL-37 shows a great potential to be further investigated and developed as a drug with clinical use. (C) 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.
引用
收藏
页码：802 / 808
页数：7
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