LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity

被引：121

作者：

Fabisiak, Adam ^{[1
,2
]}

Murawska, Natalia ^{[1
,2
]}

Fichna, Jakub ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Biochem, Fac Med, Lodz, Poland

[2] Med Univ Lodz, Dept Pathol, Fac Med, Lodz, Poland

来源：

PHARMACOLOGICAL REPORTS | 2016年 / 68卷 / 04期

关键词：

Cathelicidin; LL-37; Antimicrobial peptide; OBSTRUCTIVE PULMONARY-DISEASE; NEUTROPHIL EXTRACELLULAR TRAPS; INFLAMMATORY BOWEL DISEASES; CONTROLLED CLINICAL-TRIAL; ALPHA-HELICAL PEPTIDES; AIRWAY SURFACE FLUID; ATOPIC-DERMATITIS; HUMAN MACROPHAGES; CYSTIC-FIBROSIS; IN-VIVO;

D O I：

10.1016/j.pharep.2016.03.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antimicrobial peptides (AMPs) is a large family of compounds serving as natural antibiotics, widely distributed across the organism, mainly in mucus layers. They are designed to prevent pathogens from colonization. Among them, defensins and cathelicidins could be found. LL-37, the sole human cathelicidin draws particular attention because of its outstanding abilities. In addition to being a broad spectrum antibiotic, LL-37 has potent chemotactic and immunomodulatory properties. In this review, we discussed the potency of LL-37 as a therapeutic agent in four systems: immunological, respiratory, gastrointestinal and in the skin. We analyzed the main molecular pathways dependent on human cathelicidin and related them to specific diseases. We conclude that LL-37 shows a great potential to be further investigated and developed as a drug with clinical use. (C) 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.

引用

页码：802 / 808

页数：7

共 90 条

[51] Regulation of Cathelicidin Antimicrobial Peptide Expression by an Endoplasmic Reticulum (ER) Stress Signaling, Vitamin D Receptor-independent Pathway [J].

Park, Kyungho ;

Elias, Peter M. ;

Oda, Yuko ;

Mackenzie, Donald ;

Mauro, Theodora ;

Holleran, Walter M. ;

Uchida, Yoshikazu .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (39) :34121-34130

[52] Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37 [J].

Pazgier, Marzena ;

Ericksen, Bryan ;

Ling, Minhua ;

Toth, Eric ;

Shi, Jishu ;

Li, Xiangdong ;

Galliher-Beckley, Amy ;

Lan, Liqiong ;

Zou, Guozhang ;

Zhan, Changyou ;

Yuan, Weirong ;

Pozharski, Edwin ;

Lu, Wuyuan .

BIOCHEMISTRY, 2013, 52 (09) :1547-1558

[53] IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes [J].

Peric, Mark ;

Koglin, Sarah ;

Kim, Song-Min ;

Morizane, Shin ;

Besch, Robert ;

Prinz, Joerg C. ;

Ruzicka, Thomas ;

Gallo, Richard L. ;

Schauber, Juergen .

JOURNAL OF IMMUNOLOGY, 2008, 181 (12) :8504-8512

[54] Vitamin D Analogs Differentially Control Antimicrobial Peptide/"Alarmin" Expression in Psoriasis [J].

Peric, Mark ;

Koglin, Sarah ;

Dombrowski, Yvonne ;

Gross, Katrin ;

Bradac, Eva ;

Buechau, Amanda ;

Steinmeyer, Andreas ;

Zuegel, Ulrich ;

Ruzicka, Thomas ;

Schauber, Juergen .

PLOS ONE, 2009, 4 (07)

[55] Cathelicidin Antimicrobial Peptide: A Novel Regulator of Islet Function, Islet Regeneration, and Selected Gut Bacteria [J].

Pound, Lynley D. ;

Patrick, Christopher ;

Eberhard, Chandra E. ;

Mottawea, Walid ;

Wang, Gen-Sheng ;

Abujamel, Turki ;

Vandenbeek, Roxanne ;

Stintzi, Alain ;

Scott, Fraser W. .

DIABETES, 2015, 64 (12) :4135-4147

[56] Pulmonary tuberculosis patients with a Vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells [J].

Rahman, Sayma ;

Rehn, Anders ;

Rahman, Jubayer ;

Andersson, Jan ;

Svensson, Mattias ;

Brighenti, Susanna .

CLINICAL IMMUNOLOGY, 2015, 156 (02) :85-97

[57] Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial [J].

Raqib, Rubhana ;

Sarker, Protim ;

Mily, Akhirunnesa ;

Alam, Nur Haque ;

Arifuzzaman, Abu Saleh Mohammed ;

Rekha, Rokeya Sultana ;

Andersson, Jan ;

Gudmundsson, Gudmundur H. ;

Cravioto, Alejandro ;

Agerberth, Birgitta .

BMC INFECTIOUS DISEASES, 2012, 12

[58] Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer [J].

Ren, Shun X. ;

Cheng, Alfred S. L. ;

To, Ka F. ;

Tong, Joanna H. M. ;

Li, May S. ;

Shen, Jin ;

Wong, Clover C. M. ;

Zhang, Lin ;

Chan, Ruby L. Y. ;

Wang, Xiao J. ;

Ng, Simon S. M. ;

Chiu, Lawrence C. M. ;

Marquez, Victor E. ;

Gallo, Richard L. ;

Chan, Francis K. L. ;

Yu, Jun ;

Sung, Joseph J. Y. ;

Wu, William K. K. ;

Cho, Chi H. .

CANCER RESEARCH, 2012, 72 (24) :6512-6523

[59] TLR9 mRNA Expression Is Upregulated in Patients with Active Ulcerative Colitis [J].

Sanchez-Munoz, Fausto ;

Fonseca-Camarillo, Gabriela C. ;

Villeda-Ramirez, Marco A. ;

Barreto-Zuniga, Rafael ;

Bojalil, Rafael ;

Dominguez-Lopez, Aaron ;

Uribe, Misael ;

Yamamoto-Furusho, Jesus K. .

INFLAMMATORY BOWEL DISEASES, 2010, 16 (08) :1267-1268

[60] The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis [J].

Sandgren, S ;

Wittrup, A ;

Cheng, F ;

Jönsson, M ;

Eklund, E ;

Busch, S ;

Belting, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (17) :17951-17956

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