The antiulcer activity of Garcinia cambogia extract against indomethacin induced gastric ulcer in rats

被引：41
作者：
Mahendran, P [1 ]
Vanisree, AJ [1 ]
Devi, CSS [1 ]
机构：
[1] Univ Madras, Dept Biochem & Mol Biol, Chennai 600025, India
来源：
PHYTOTHERAPY RESEARCH | 2002年 / 16卷 / 01期
关键词：
gastric ulcer; Garcinia cambogia; indomethacin; antiulcer activity;
D O I：
10.1002/ptr.946
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Garcinia cambogia extract is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. In the present study this drug was tested for its antiulcerogenic effect. Oral pretreatment with Garcinia cambogia fruit extract (1 g/kg body wt/day) for 5, 10 or 15 days protected the gastric mucosa against the damage induced by indomethacin (20 mg/kg body wt). The volume and acidity of the gastric juice decreased in the pretreated rats. The glycoprotein levels of the gastric contents which were decreased in the untreated rats, maintained near normal levels in the pretreated rats. Protein which was elevated in the gastric juice of untreated rats, showed near normal levels in the pretreated rats. Garcinia cambogia was able to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent. Copyright 2002 John Wiley Sons, Ltd.
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页码：80 / 83
页数：4
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