Bioactivities and Structure-Activity Relationships of Natural Tetrahydroanthraquinone Compounds: A Review

被引：12

作者：

Feng, Shixiu ^{[1
]}

Wang, Weiyi ^{[2
]}

机构：

[1] Shenzhen & Chinese Acad Sci, Fairy Lake Bot Garden, Key Lab South Subtrop Plant Div, Shenzhen, Peoples R China

[2] Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

tetrahydroanthraquinone; anti-cancer; structure-activity relationship; bioactivities; altersolanol A; bostrycin; FUNGUS STEMPHYLIUM-GLOBULIFERUM; ENDOPHYTIC FUNGUS; ANTHRAQUINONE DERIVATIVES; PRISMATOMERIS-CONNATA; MARINE ANTHRAQUINONE; ANTICANCER ACTIVITY; CELLS; METABOLITES; APOPTOSIS; SZ-685C;

D O I：

10.3389/fphar.2020.00799

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tetrahydroanthraquinones are a kind of important microbial secondary metabolites with promising biological activities. Most of them were found in microorganisms, a few were derived from Chinese herbal medicine. In this review, aiming to provide basis for the further research and development of tetrahydroanthraquinone compounds, we summarized the physiological activities of natural tetrahydroanthraquinone compounds, including anti-cancer, anti-microbial, and antidiabetic activities. The source, structure, and action mechanisms of active tetrahydroanthraquinones are described in detail. Furthermore, this review firstly analyzed the structure-activity relationship of tetrahydroanthraquinones. Our study will serve as a valuable guideline for further research on the structural optimization, mechanism study, and development of tetrahydroanthraquinone as novel drugs. Aiming to provide references for further studies and development of tetrahydroanthraquinone compounds.

引用

页数：10

共 46 条

[1] Bioactive metabolites from the endophytic fungus Ampelomyces sp isolated from the medicinal plant Urospermum picroides [J].

Aly, Amal H. ;

Edrada-Ebel, RuAngelie ;

Wray, Victor ;

Mueller, Werner E. G. ;

Kozytska, Svitlana ;

Hentschel, Ute ;

Proksch, Peter ;

Ebel, Rainer .

PHYTOCHEMISTRY, 2008, 69 (08) :1716-1725

[2]

[Anonymous], 2016, International Journal of Pharmacy and Pharmaceutical Sciences

[3] METABOLITES OF DACTYLARIA-LUTEA - STRUCTURES OF DACTYLARIOL AND ANTI-PROTOZOAL ANTIBIOTIC DACTYLARIN [J].

BECKER, AM ;

RICKARDS, RW ;

SCHMALZL, KJ ;

YICK, HC .

JOURNAL OF ANTIBIOTICS, 1978, 31 (04) :324-329

[4]

[陈彬 Chen Bin], 2016, [中山大学学报. 自然科学版, Acta Scientiarum Naturalium Universitatis Sunyatseni], V55, P91

[5] The Anthraquinone Derivatives from the Fungus Alternaria sp XZSBG-1 from the Saline Lake in Bange, Tibet, China [J].

Chen, Bin ;

Shen, Qiong ;

Zhu, Xun ;

Lin, Yongcheng .

MOLECULES, 2014, 19 (10) :16529-16542

[6] A Novel Marine Drug, SZ-685C, Induces Apoptosis of MMQ Pituitary Tumor Cells by Downregulating miR-200c [J].

Chen, C. -H. ;

Xiao, W. -W. ;

Jiang, X. -B. ;

Wang, J. -W. ;

Mao, Z. -G. ;

Lei, N. ;

Fan, X. ;

Song, B. -B. ;

Liao, C. -X. ;

Wang, H. -J. ;

She, Z. -G. ;

Zhu, Y. -H. .

CURRENT MEDICINAL CHEMISTRY, 2013, 20 (16) :2145-2154

[7] Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells [J].

Chen, Hong ;

Zhong, Lili ;

Long, Yuhua ;

Li, Jia ;

Wu, Jueheng ;

Liu, Lan ;

Chen, Shengping ;

Lin, Yongcheng ;

Li, Mengfeng ;

Zhu, Xun ;

She, Zhigang .

MARINE DRUGS, 2012, 10 (04) :932-952

[8] Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway [J].

Chen, Wei-Sheng ;

Hou, Jun-Na ;

Guo, Yu-Biao ;

Yang, Hui-Ling ;

Xie, Can-Mao ;

Lin, Yong-Cheng ;

She, Zhi-Gang .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2011, 30

[9] Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold [J].

Choomuenwai, Vanida ;

Andrews, Katherine T. ;

Davis, Rohan A. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (24) :7167-7174

[10] Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium [J].

Debbab, Abdessamad ;

Aly, Amal H. ;

Edrada-Ebel, RuAngelie ;

Wray, Victor ;

Mueller, Werner E. G. ;

Totzke, Frank ;

Zirrgiebel, Ute ;

Schaechtele, Christoph ;

Kubbutat, Michael H. G. ;

Lin, Wen Han ;

Mosaddak, Mahjouba ;

Hakiki, Abdelhak ;

Proksch, Peter ;

Ebel, Rainer .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (04) :626-631

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