COPD Exacerbations Causes, Prevention, and Treatment

被引：28

作者：

Mackay, Alex J. ^{[1
]}

Hurst, John R. ^{[1
]}

机构：

[1] UCL Med Sch, Acad Unit Resp Med, London NW3 2PF, England

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2012年 / 96卷 / 04期

关键词：

Chronic obstructive pulmonary disease; Exacerbation; Respiratory viruses; Bacteria; OBSTRUCTIVE PULMONARY-DISEASE; HISTONE DEACETYLASE ACTIVITY; RESPIRATORY SYNCYTIAL VIRUS; SLOW-RELEASE THEOPHYLLINE; VOLUME-REDUCTION SURGERY; AIRWAY INFLAMMATION; LUNG-FUNCTION; DOUBLE-BLIND; PNEUMOCOCCAL VACCINATION; FLUTICASONE PROPIONATE;

D O I：

10.1016/j.mcna.2012.02.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanisms of chronic obstructive pulmonary disease exacerbation are complex. Respiratory viruses (in particular rhinovirus) and bacteria play a major role in the cause of these events. A distinct group of patients seems susceptible to frequent exacerbations, irrespective of disease severity, and this phenotype is stable over time. Many current therapeutic strategies help reduce exacerbation frequency. Further work is required to develop novel anti-inflammatory therapies for exacerbation prevention and treatment. This article focuses on the cause of chronic obstructive pulmonary disease exacerbations, and the current preventative and acute interventions available.

引用

页码：789 / +

页数：22

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