Controllable structure, properties, and degradation of the electrospun PLGA/PLA-blended nanofibrous scaffolds

被引：49
作者：
Liu, Hua [1 ,2 ]
Wang, Shudong [1 ,2 ]
Qi, Ning [3 ]
机构：
[1] Coll Yancheng Text Vocat Technol, Dept Text Engn, Yancheng 224005, Peoples R China
[2] Yancheng Coll Text Technol, Jiangsu R&D Ctr Ecol Text Engn & Technol, Yancheng 224005, Peoples R China
[3] Soochow Univ, Coll Text & Clothing Engn, Suzhou 215021, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2012年 / 125卷
关键词：
electrospinning; PLGA; PLA; controllable properties; degradation; IN-VITRO; PLA; WETTABILITY; CHITOSAN; DESIGN;
D O I：
10.1002/app.36757
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this research, the PLGA/PLA-blended nanofibers were successfully prepared by electrospinning. The macromicro structure, thermal stability, hydrophilicity, mechanical properties, and in vitro degradation of the electrospun PLGA/PLA nanofibrous scaffolds are characterized by means of SEM, FTIR, DSC, TG, contact angle, instron tensile tester, and degradation testing. The results showed that electrospun PLGA/PLA-blended nanofibrous scaffolds possessed nanofibrous and porous structures. The structural stability, crystallinity, wettability, and mechanical properties, especially the in vitro degradation rate, of the electrospun PLGA/PLA-blended nanofibrous scaffolds could be controlled by regulating the blended ratio of the poly(lactide-co-glycolide) (PLGA) and poly(lactide) (PLA). The results indicated that the electrospun PLGA/PLA-blended nanofibrous scaffolds could be considered as ideal candidates for tissue engineering scaffolds.(C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
引用
收藏
页码：E468 / E476
页数：9
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