Role of COMT in ADHD: a Systematic Meta-Analysis

被引：42
作者：
Sun, Hongjuan
Yuan, Fangfen
Shen, Xuemei
Xiong, Guanglian
Wu, Jing [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2014年 / 49卷 / 01期
关键词：
ADHD; COMT; Meta-analysis; CATECHOL-O-METHYLTRANSFERASE; DEFICIT-HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; OBSESSIVE-COMPULSIVE DISORDER; MEDIAL PREFRONTAL CORTEX; LOW ACTIVITY ALLELE; METHYL-TRANSFERASE GENE; GENOME-WIDE ASSOCIATION; HUMAN BASAL GANGLIA; DOPAMINE TRANSPORTER;
D O I：
10.1007/s12035-013-8516-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable childhood-onset psychiatric disorder with significant genetic contribution. Considerable evidence has implicated involvement of dopaminergic system and the prefrontal cortex (PFC) in the pathomechanism of ADHD. The catechol-O-methyltransferase (COMT) gene is of particular interest for ADHD as its crucial role in the degradation of dopamine in the PFC. We summarized the reported findings investigating associations between COMT gene and ADHD and performed a meta-analysis of previous studies to assess the overall magnitude and significance of the association.
引用
收藏
页码：251 / 261
页数：11
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