共 59 条
Enhanced Therapeutic Effects Conferred by an Experimental DNA Vaccine Targeting Human Papillomavirus-Induced Tumors
被引:23
作者:

Diniz, Mariana O.
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Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil

Cariri, Francisco A. M. O.
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Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil

Aps, Luana R. M. M.
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Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil

Ferreira, Luis C. S.
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机构:
Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil
机构:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, Brazil
关键词:
T-CELL RESPONSES;
CERVICAL INTRAEPITHELIAL NEOPLASIA;
IMMUNE-RESPONSES;
FUSION PROTEIN;
IN-VIVO;
CANCER PATIENTS;
GLYCOPROTEIN-D;
CTL RESPONSES;
TYPE-16;
E6;
GM-CSF;
D O I:
10.1089/hum.2013.102
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Human papillomavirus (HPV) infection is responsible for all cervical cancer cases, other anogenital cancers, and head and neck tumors. The epidemiological relevance of HPV-induced tumors reinforces the need for the development of therapeutic antitumor vaccines. Clinical trials with different vaccine formulations, particularly DNA vaccines, have provided promising results but have still been unable to achieve the immunogenicity required for use in infected patients. In experimental conditions, anticancer HPV-specific vaccines induced E7-specific CD8(+) T-cell responses but did not confer full therapeutic antitumor protection in mice with transplanted HPV-expressing TC-1 cells, which are the most frequently used nonclinical protection correlate for antitumor effects. Our group has developed a DNA vaccine strategy based on the fusion of HPV oncoproteins to the herpes virus gD protein. This vaccine promoted the induction of antigen-specific cytotoxic CD8(+) T-cell responses and partial antitumor therapeutic effects based on the blockade of coinhibitory signals and the enhancement of coactivation mechanisms. In the present study, we report conditions leading to full therapeutic antitumor effects using the TC-1 cell murine model after a single vaccine dose. The combination of a coadministered plasmid encoding IL-2, optimization of the coding sequence for mammalian cells, and the use of different delivery routes resulted in enhancements of the E7-specific cytotoxic CD8(+) T-cell responses and full therapeutic protection under experimental conditions. The combination of these strategies augmented the potency of the DNA vaccine formulation to levels not previously achieved by other therapeutic antitumor vaccines under similar experimental conditions, including some that have been taken to clinical trials.
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收藏
页码:861 / 870
页数:10
相关论文
共 59 条
[41]
Purified Herpes Simplex Type 1 Glycoprotein D (gD) Genetically Fused with the Type 16 Human Papillomavirus E7 Oncoprotein Enhances Antigen-Specific CD8+ T Cell Responses and Confers Protective Antitumor Immunity
[J].
Porchia, Brum. F. M. M.
;
Diniz, Mariana O.
;
Cariri, Francisco A. M. O.
;
Santana, Vinicius C.
;
Amorim, Jaime H.
;
Balan, Andrea
;
Braga, Catarina J. M.
;
Ferreira, Luis Carlos S.
.
MOLECULAR PHARMACEUTICS,
2011, 8 (06)
:2320-2330

Porchia, Brum. F. M. M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

Diniz, Mariana O.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

Cariri, Francisco A. M. O.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

Santana, Vinicius C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

Amorim, Jaime H.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

Balan, Andrea
论文数: 0 引用数: 0
h-index: 0
机构:
Brazilian Natl Lab Biosci LNBio, Ctr Res Energy & Mat, Campinas, SP, Brazil Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

Braga, Catarina J. M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

Ferreira, Luis Carlos S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil Univ Sao Paulo, ICB II, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil
[42]
EXPERIENCE WITH THE USE OF HIGH-DOSE INTERLEUKIN-2 IN THE TREATMENT OF 652 CANCER-PATIENTS
[J].
ROSENBERG, SA
;
LOTZE, MT
;
YANG, JC
;
AEBERSOLD, PM
;
LINEHAN, WM
;
SEIPP, CA
;
WHITE, DE
.
ANNALS OF SURGERY,
1989, 210 (04)
:474-485

ROSENBERG, SA
论文数: 0 引用数: 0
h-index: 0

LOTZE, MT
论文数: 0 引用数: 0
h-index: 0

YANG, JC
论文数: 0 引用数: 0
h-index: 0

AEBERSOLD, PM
论文数: 0 引用数: 0
h-index: 0

LINEHAN, WM
论文数: 0 引用数: 0
h-index: 0

SEIPP, CA
论文数: 0 引用数: 0
h-index: 0

WHITE, DE
论文数: 0 引用数: 0
h-index: 0
[43]
Involvement of HVEM receptor in activation of nuclear factor κB by herpes simplex virus 1 glycoprotein D
[J].
Sciortino, Maria Teresa
;
Medici, Maria Antonietta
;
Marino-Merlo, Francesca
;
Zaccaria, Daniela
;
Giuffre-Cuculletto, Maria
;
Venuti, Assunta
;
Grelli, Sandro
;
Mastino, Antonio
.
CELLULAR MICROBIOLOGY,
2008, 10 (11)
:2297-2311

Sciortino, Maria Teresa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy

Medici, Maria Antonietta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy

Marino-Merlo, Francesca
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy

Zaccaria, Daniela
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy

Giuffre-Cuculletto, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy

论文数: 引用数:
h-index:
机构:

Grelli, Sandro
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy

Mastino, Antonio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy
IRCCS Ctr Neurolesi Bonino Pulejo, Messina, Italy Univ Messina, Dept Life Sci, Sect Microbiol Genet & Mol Sci, I-98166 Messina, Italy
[44]
Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA
[J].
Sheets, EE
;
Urban, RG
;
Crum, CP
;
Hedley, ML
;
Politch, JA
;
Gold, MA
;
Muderspach, LI
;
Cole, GA
;
Crowley-Nowick, PA
.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY,
2003, 188 (04)
:916-926

Sheets, EE
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Urban, RG
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Crum, CP
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Hedley, ML
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Politch, JA
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Gold, MA
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Muderspach, LI
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Cole, GA
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

Crowley-Nowick, PA
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA
[45]
Regulation of T-helper-1 versus T-helper-2 activity and enhancement of tumor immunity by combined DNA-based vaccination and nonviral cytokine gene transfer
[J].
Song, K
;
Chang, Y
;
Prud'homme, GJ
.
GENE THERAPY,
2000, 7 (06)
:481-492

Song, K
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada

Chang, Y
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada

Prud'homme, GJ
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada
[46]
The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation
[J].
Steinberg, Marcos W.
;
Cheung, Timothy C.
;
Ware, Carl F.
.
IMMUNOLOGICAL REVIEWS,
2011, 244
:169-187

Steinberg, Marcos W.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanford Burnham Med Res Inst, Ctr Infect & Inflammatory Dis, Lab Mol Immunol, La Jolla, CA 92037 USA Sanford Burnham Med Res Inst, Ctr Infect & Inflammatory Dis, Lab Mol Immunol, La Jolla, CA 92037 USA

Cheung, Timothy C.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanford Burnham Med Res Inst, Ctr Infect & Inflammatory Dis, Lab Mol Immunol, La Jolla, CA 92037 USA Sanford Burnham Med Res Inst, Ctr Infect & Inflammatory Dis, Lab Mol Immunol, La Jolla, CA 92037 USA

Ware, Carl F.
论文数: 0 引用数: 0
h-index: 0
机构:
Sanford Burnham Med Res Inst, Ctr Infect & Inflammatory Dis, Lab Mol Immunol, La Jolla, CA 92037 USA Sanford Burnham Med Res Inst, Ctr Infect & Inflammatory Dis, Lab Mol Immunol, La Jolla, CA 92037 USA
[47]
Enhancement of the immunogenicity of an alphavirus replicon-based DNA vaccine against classical swine fever by electroporation and coinjection with a plasmid expressing porcine interleukin 2
[J].
Tian, Da-Yong
;
Sun, Yuan
;
Wai, Sing Fai
;
Lee, Fuk Ki
;
Meng, Qi-Lin
;
Suen, Kar Man
;
Wang, Nan
;
Han, Wen
;
Li, Su
;
Li, Yong-Feng
;
Li, Dan
;
Ling, Li-Jun
;
Liao, Ya-Jin
;
Qiu, Hua-Ji
.
VACCINE,
2012, 30 (24)
:3587-3594

Tian, Da-Yong
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Sun, Yuan
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Wai, Sing Fai
论文数: 0 引用数: 0
h-index: 0
机构:
GreenPak Biotech Ltd, Hong Kong, Hong Kong, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Lee, Fuk Ki
论文数: 0 引用数: 0
h-index: 0
机构:
GreenPak Biotech Ltd, Hong Kong, Hong Kong, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Meng, Qi-Lin
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Suen, Kar Man
论文数: 0 引用数: 0
h-index: 0
机构:
GreenPak Biotech Ltd, Hong Kong, Hong Kong, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Wang, Nan
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Han, Wen
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Li, Su
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Li, Yong-Feng
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Li, Dan
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Ling, Li-Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Liao, Ya-Jin
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

Qiu, Hua-Ji
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China Chinese Acad Agr Sci, Div Swine Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China
[48]
The combination of GM-CSF and IL-2 as local adjuvant shows synergy in enhancing peptide vaccines and provides long term tumor protection
[J].
Toubaji, Antoun
;
Hill, Sarah
;
Terabe, Masaki
;
Qian, Jiahua
;
Floyd, Tamara
;
Simpson, R. Mark
;
Berzofsky, Jay A.
;
Khleif, Samir N.
.
VACCINE,
2007, 25 (31)
:5882-5891

Toubaji, Antoun
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA

Hill, Sarah
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA

Terabe, Masaki
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA

Qian, Jiahua
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA

Floyd, Tamara
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA

Simpson, R. Mark
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA

Berzofsky, Jay A.
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA

Khleif, Samir N.
论文数: 0 引用数: 0
h-index: 0
机构: NIH, NCI, Vaccine Branch, Canc Vaccine Sect, Bethesda, MD 20892 USA
[49]
Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia
[J].
Van Doorslaer, Koenraad
;
Reimers, Laura L.
;
Studentsov, Yevgeniy Y.
;
Einstein, Mark H.
;
Burk, Robert D.
.
GYNECOLOGIC ONCOLOGY,
2010, 116 (02)
:208-212

Van Doorslaer, Koenraad
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

Reimers, Laura L.
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

Studentsov, Yevgeniy Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

Einstein, Mark H.
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10461 USA
Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

Burk, Robert D.
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA
Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
[50]
Vaccine-Induced Effector-Memory CD8+ T Cell Responses Predict Therapeutic Efficacy against Tumors
[J].
van Duikeren, Suzanne
;
Fransen, Marieke F.
;
Redeker, Anke
;
Wieles, Brigitte
;
Platenburg, Gerard
;
Krebber, Willem-Jan
;
Ossendorp, Ferry
;
Melief, Cornelis J. M.
;
Arens, Ramon
.
JOURNAL OF IMMUNOLOGY,
2012, 189 (07)
:3397-3403

van Duikeren, Suzanne
论文数: 0 引用数: 0
h-index: 0
机构:
Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands

Fransen, Marieke F.
论文数: 0 引用数: 0
h-index: 0
机构:
Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands

Redeker, Anke
论文数: 0 引用数: 0
h-index: 0
机构:
Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands

Wieles, Brigitte
论文数: 0 引用数: 0
h-index: 0
机构:
Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands

Platenburg, Gerard
论文数: 0 引用数: 0
h-index: 0
机构:
ISA Therapeut BV, NL-2333 CA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands

Krebber, Willem-Jan
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Ossendorp, Ferry
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Melief, Cornelis J. M.
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Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands
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Arens, Ramon
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