Identification and quantification of the doping agent GHRP-2 in seized unlabelled vials by NMR and MS: a case- report

被引:14
作者
Gaudiano, Maria Cristina [1 ]
Valvo, Luisa [1 ]
Borioni, Anna [1 ]
机构
[1] Ist Super Sanita, Dipartimento Farmaco, I-00161 Rome, Italy
关键词
PEPTIDE-2; GHRP-2; HORMONE; H-1-NMR;
D O I
10.1002/dta.1603
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:295 / 300
页数:6
相关论文
共 18 条
[1]  
Di Giorgio D., 2011, COUNTERFEIT MED DETE
[2]   Combined nuclear magnetic resonance spectroscopy and molecular dynamics study of growth hormone releasing hexapeptide GHRP-6 and a cyclic analogue [J].
Fernandez-Oliva, Miguel ;
Santana, Hector ;
Suardiaz, Reynier ;
Gavin, Jose A. ;
Perez, Carlos S. .
MAGNETIC RESONANCE IN CHEMISTRY, 2012, 50 (05) :364-371
[3]   A Survey on Illegal and Counterfeit Medicines for the Treatment of Erectile Dysfunctions in Italy [J].
Gaudiano, Maria Cristina ;
Manna, Livia ;
Rodomonte, Andrea Luca ;
Bartolomei, Monica ;
Bertocchi, Paola ;
Gallinella, Bruno ;
Antoniella, Eleonora ;
Muleri, Nadia ;
Civitelli, Gabriele ;
Alimonti, Stefano ;
Romanini, Laura ;
Rufini, Leandro ;
Valvo, Luisa .
JOURNAL OF SEXUAL MEDICINE, 2012, 9 (08) :2130-2137
[4]   Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation [J].
Henninge, John ;
Pepaj, Milaim ;
Hullstein, Ingunn ;
Hemmersbach, Peter .
DRUG TESTING AND ANALYSIS, 2010, 2 (11-12) :647-650
[5]   Improving the efficiency of quantitative 1H NMR: An innovative external standard-internal reference approach [J].
Huang, Yande ;
Su, Bao-Ning ;
Ye, Qingmei ;
Palaniswamy, Venkatapuram A. ;
Bolgar, Mark S. ;
Raglione, Thomas V. .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 88 :1-6
[6]  
Jacobsen NE, 2007, NMR SPECTROSCOPY EXPLAINED: SIMPLIFIED THEORY, APPLICATIONS AND EXAMPLES FOR ORGANIC CHEMISTRY AND STRUCTURAL BIOLOGY, P489
[7]   Confiscated Black Market Products and Nutritional Supplements with Non-Approved Ingredients Analyzed in the Cologne Doping Control Laboratory 2009 [J].
Kohler, Maxie ;
Thomas, Andreas ;
Geyer, Hans ;
Petrou, Michael ;
Schaenzer, Wilhelm ;
Thevisa, Mario .
DRUG TESTING AND ANALYSIS, 2010, 2 (11-12) :533-537
[8]   Quantification of organic and amino acids in beer by 1H NMR spectroscopy [J].
Nord, LI ;
Vaag, P ;
Duus, JO .
ANALYTICAL CHEMISTRY, 2004, 76 (16) :4790-4798
[9]   Influence of intravenous administration of growth hormone releasing peptide-2 (GHRP-2) on detection of growth hormone doping: growth hormone isoform profiles in Japanese male subjects [J].
Okano, Masato ;
Nishitani, Yasunori ;
Sato, Mitsuhiko ;
Ikekita, Ayako ;
Kageyama, Shinji .
DRUG TESTING AND ANALYSIS, 2010, 2 (11-12) :548-556
[10]   Determination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry [J].
Okano, Masato ;
Sato, Mitsuhiko ;
Ikekita, Ayako ;
Kageyama, Shinji .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2010, 24 (14) :2046-2056