OMALIZUMAB A NEW PROSPECTIVE: A NASAL POLYPOSIS

被引:0
作者
Cavaliere, C. [1 ]
Begvarfaj, E. [2 ]
Frati, F. [3 ]
Masieri, S. [2 ]
机构
[1] Sapienza Univ, Dept Oral & Maxillofacial Sci, Rome, Italy
[2] Sapienza Univ, Dept Sense Organs, Rome, Italy
[3] Univ Perugia, Dept Surg & Biomed Sci, Pediat Clin, Perugia, Italy
关键词
Omalizumab; nasal polyposis; chronic rhinosinusitis; ENDOSCOPIC SINUS SURGERY; CHRONIC RHINOSINUSITIS; ALLERGIC RHINITIS; ANTI-IGE; RECURRENCE; PREVALENCE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Omalizumab, a monoclonal antibody against IgE, may be effective on nasal polyps, but its use is not currently authorized to treat that disease. We report the cases of three patients who were given omalizumab for asthma after undergoing nasal surgical polypectomy. Although such procedure is frequently followed by polyp recurrence, none of the three patients developed this complication, and in one subject the regression of initial polyp return was registered after starting omalizumab. Our data support the hypothesis that omalizumab may be useful to treat nasal polyposis.
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收藏
页码:167 / 169
页数:3
相关论文
共 16 条
  • [1] Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis
    Ädelroth, E
    Rak, S
    Haahtela, T
    Aasand, G
    Rosenhall, L
    Zetterstrom, O
    Byrne, A
    Champain, K
    Thirlwell, J
    Della Cioppa, G
    Sandström, T
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (02) : 253 - 259
  • [2] Role of Frontal Sinus Surgery in Nasal Polyp Recurrence
    Bassiouni, Ahmed
    Wormald, Peter-John
    [J]. LARYNGOSCOPE, 2013, 123 (01) : 36 - 41
  • [3] Effect of omalizumab on symptoms of seasonal allergic rhinitis - A randomized controlled trial
    Casale, TB
    Condemi, J
    LaForce, C
    Nayak, A
    Rowe, M
    Watrous, M
    McAlary, M
    Fowler-Taylor, A
    Racine, M
    Gupta, N
    Fick, R
    Della Cioppa, G
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (23): : 2956 - 2967
  • [4] Prevalence of Polyp Recurrence After Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyposis
    DeConde, Adam S.
    Mace, Jess C.
    Levy, Joshua M.
    Rudmik, Luke
    Alt, Jeremiah A.
    Smith, Timothy L.
    [J]. LARYNGOSCOPE, 2017, 127 (03) : 550 - 555
  • [5] Fokkens WJ, 2012, RHINOLOGY, V50, P1, DOI 10.4193/Rhin20.600
  • [6] Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    Gevaert, Philippe
    Calus, Lien
    Van Zele, Thibaut
    Blomme, Katrien
    De Ruyck, Natalie
    Bauters, Wouter
    Hellings, Peter
    Brusselle, Guy
    De Bacquer, Dirk
    van Cauwenberge, Paul
    Bachert, Claus
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (01) : 110 - U166
  • [7] Long-Term Outcomes From the English National Comparative Audit of Surgery for Nasal Polyposis and Chronic Rhinosinusitis
    Hopkins, Claire
    Slack, Robert
    Lund, Valerie
    Brown, Peter
    Copley, Lynn
    Browne, John
    [J]. LARYNGOSCOPE, 2009, 119 (12) : 2459 - 2465
  • [8] Omalizumab, an anti-immunoglobulin E antibody: state of the art
    Incorvaia, Cristoforo
    Mauro, Marina
    Russello, Marina
    Formigoni, Chiara
    Riario-Sforza, Gian Galeazzo
    Ridolo, Erminia
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2014, 8 : 197 - 207
  • [9] Masieri S, 2016, EUR REV MED PHARMACO, V20, P5249
  • [10] Mendelsohn D, ANN OTOL RHINOL LARY, V120, P162