Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study

被引：17

作者：

Kakuta, E. ^{[1
]}

Nomura, Y. ^{[2
]}

Morozumi, T. ^{[3
]}

Nakagawa, T. ^{[4
]}

Nakamura, T. ^{[5
]}

Noguchi, K. ^{[5
]}

Yoshimura, A. ^{[6
]}

Hara, Y. ^{[6
]}

Fujise, O. ^{[7
]}

Nishimura, F. ^{[7
]}

Kono, T. ^{[8
]}

Umeda, M. ^{[8
]}

Fukuda, M. ^{[9
]}

Noguchi, T. ^{[9
]}

Yoshinari, N. ^{[10
]}

Fukaya, C. ^{[4
]}

Sekino, S. ^{[11
]}

Numabe, Y. ^{[11
]}

Sugano, N. ^{[12
]}

Ito, K. ^{[12
]}

Kobayashi, H. ^{[13
]}

Izumi, Y. ^{[13
]}

Takai, H. ^{[14
]}

Ogata, Y. ^{[14
]}

Takano, S. ^{[15
]}

Minabe, M. ^{[15
,16
]}

Makino-Oi, A. ^{[17
]}

Saito, A. ^{[17
]}

Abe, Y. ^{[18
]}

Sato, S. ^{[19
]}

Suzuki, F. ^{[20
]}

Takahashi, K. ^{[21
]}

Sugaya, T. ^{[22
]}

Kawanami, M. ^{[22
]}

Hanada, N. ^{[2
]}

Takashiba, S. ^{[23
]}

Yoshie, H. ^{[3
]}

机构：

[1] Tsurumi Univ, Sch Dent Med, Dept Oral Microbiol, Tsurumi Ku, 2-1-3 Tsurumi, Yokohama, Kanagawa, Japan

[2] Tsurumi Univ, Sch Dent Med, Dept Translat Res, Tsurumi Ku, 2-1-3 Tsurumi, Yokohama, Kanagawa, Japan

[3] Niigata Univ, Grad Sch Med & Dent Sci, Dept Oral Biol Sci, Div Periodontol,Chuo Ku, 2-5274 Gakkocho Dori, Niigata, Japan

[4] Keio Univ, Sch Med, Dept Dent & Oral Surg, Shinjuku Ku, 35 Shinano Machi, Tokyo, Japan

[5] Kagoshima Univ, Dept Periodontol, Grad Sch Med & Dent Sci, 8-35-1 Sakuragaoka, Kagoshima, Japan

[6] Nagasaki Univ, Dept Periodontol, Unit Translat Med, Grad Sch Biomed Sci, 1-12-4 Sakamoto, Nagasaki, Japan

[7] Kyushu Univ, Fac Dent Sci, Div Oral Rehabil, Sect Periodontol,Higashi Ku, 3-1-1 Maidashi, Fukuoka, Japan

[8] Osaka Dent Univ, Dept Periodontol, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, Japan

[9] Aichi Gakuin Univ, Sch Dent, Dept Periodontol, Chikusa Ku, 2-11 Suemori Doori, Nagoya, Aichi, Japan

[10] Matsumoto Dent Univ, Sch Dent, Dept Periodontol, 1780 Hirokagobara, Nagano, Japan

[11] Sch Life Dent Tokyo, Nippon Dent Univ, Dept Periodontol, Chiyoda Ku, 1-9-20 Fujimi, Tokyo, Japan

[12] Nihon Univ, Sch Dent, Dept Periodontol, Chiyoda Ku, 1-8-13 Kanda Surugadai, Tokyo, Japan

[13] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Periodontol, Bunkyo Ku, 1-5-45 Yushima, Tokyo, Japan

[14] Nihon Univ, Sch Dent Matsudo, Dept Periodontol, 2-870-1 Sakae Cho Nishi, Matsudo, Chiba, Japan

[15] Bunkyo Dori Dent Clin, Inage Ku, 2-4-1 Anagawa, Chiba, Japan

[16] Kanagawa Dent Univ, Sch Dent, Dept Oral Funct & Restorat, Div Periodontol, 82 Inaokacho, Yokosuka, Kanagawa, Japan

[17] Tokyo Dent Coll, Dept Periodontol, Chiyoda Ku, 2-9-18 Misakicho, Tokyo, Japan

[18] Nippon Dent Univ, Niigata Hosp, Comprehens Dent Care, Chuo Ku, 1-8 Hamaura Cho, Niigata, Japan

[19] Nippon Dent Univ, Sch Life Dent Niigata, Dept Periodontol, Chuo Ku, 1-8 Hamaura Cho, Niigata, Japan

[20] Ohu Univ, Sch Dent, Dept Oral Surg, Div Dent Anesthesiol, 31-1 Misumido, Koriyama, Fukushima, Japan

[21] Ohu Univ, Sch Dent, Dept Conservat Dent, Div Periodont, 31-1 Misumido, Koriyama, Fukushima, Japan

[22] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Hlth Sci, Div Periodontol & Endodontol,Kita Ku, Kita 13,Nishi 7, Sapporo, Hokkaido, Japan

[23] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathophysiol Periodontal Sci, 2-5-1 Shikata Cho, Okayama, Japan

来源：

BMC ORAL HEALTH | 2017年 / 17卷

关键词：

Progression of periodontitis; Periodontal stability; Porphyromonas gingivalis; Subgingival plaque; PORPHYROMONAS-GINGIVALIS; RISK-FACTORS; DISEASE; ACTINOMYCETEMCOMITANS; QUANTIFICATION; ADOLESCENTS; PREVALENCE; MANAGEMENT; MICROBIOTA; BACTERIA;

D O I：

10.1186/s12903-017-0337-x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. Methods: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Results: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). Conclusions: The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.

引用

页数：8

共 35 条

[1] METHODS OF ASSESSING RISK FOR PERIODONTITIS AND DEVELOPING MULTIFACTORIAL MODELS [J].