RHD PCR of D-Negative Blood Donors

被引：35
作者：
Wagner, Franz F. [1 ]
机构：
[1] DRK Blutspendedienst NSTOB, D-31832 Springe, Germany
来源：
TRANSFUSION MEDICINE AND HEMOTHERAPY | 2013年 / 40卷 / 03期
关键词：
Antigen D; Rh blood group; Blood donors; Indirect antiglobulin test; DEL; Weak D; RHD PCR; ANTI-D IMMUNIZATION; WEAK-D; MOLECULAR-BASIS; D-EL; DEL PHENOTYPE; AMINO-ACIDS; CELLS; GENE; ALLELE; POPULATION;
D O I：
10.1159/000351604
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
RHD PCR of blood donors may be used to reveal weak D, partial D, DEL and chimeric D+/D- donors among presumed D-negative blood donors. Units donated by such donors pose a definite yet low risk for anti-D immunization of transfusion recipients. The frequency of DEL donors among D-negative donors is 1:350 to 1:2,000 in Europe and up to 1:5 in Asian countries. Different strategies for RHD PCR of blood donors have been used. Probably, the most cost-efficient implementation is replacement of sensitive D antigen testing with the indirect antiglobulin test by RHD PCR in pools which might even reduce total testing cost.
引用
收藏
页码：172 / 181
页数：10
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