Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity

被引：8

作者：

Jaini, Ritika ^{[1
]}

Popescu, Daniela C. ^{[2
]}

Flask, Chris A. ^{[3
]}

Macklin, Wendy B. ^{[2
]}

Tuohy, Vincent K. ^{[1
,4
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Dept Immunol, Cleveland, OH 44195 USA

[2] Cleveland Clin, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA

[3] Case Western Reserve Univ, Case Ctr Imaging Res, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Cleveland Clin Lerner Coll Med, Cleveland, OH 44195 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 259卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

EAE; Microglia; Antigen load; Hypermyelination; Myelin content; Akt; EFFECTOR-CELLS; IN-VIVO; MICROGLIA; CNS; PROTEIN; AKT; PATHWAY; MODEL; OVEREXPRESSION; HYPERTROPHY;

D O I：

10.1016/j.jneuroim.2013.03.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study was designed to understand the impact of self-antigen load on manifestation of organ specific autoimmunity. Using a transgenic mouse model characterized by CNS hypermyelination, we show that larger myelin content results in greater severity of experimental autoimmune encephalomyelitis attributable to an increased number of microglia within the hypermyelinated brain. We conclude that a larger self-antigen load affects an increase in number of tissue resident antigen presenting cells (APCs) most likely due to compensatory antigen clearance mechanisms thereby enhancing the probability of productive T cell-APC interactions in an antigen abundant environment and results in enhanced severity of autoimmune disease. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：37 / 46

页数：10

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