Genotoxicity study in lymphocytes of offset printing workers

被引：21

作者：

Aksoy, H

Yilmaz, S

Çelik, M

Yüzbasioglu, D

Ünal, F

机构：

[1] Gazi Univ, Fen Edebiyat Fak, TR-06500 Ankara, Turkey

[2] Sutcu Imam Univ, Fen Edebiyat Fak, Kahramanmaras, Turkey

来源：

JOURNAL OF APPLIED TOXICOLOGY | 2006年 / 26卷 / 01期

关键词：

offset printing workers; occupational exposure; sister chromatid exchanges (SCEs); chromosome aberrations (CAs); micronuclei (MN);

D O I：

10.1002/jat.1098

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The potential cytogenetic damage in offset printing workers was evaluated using sister chromatid exchanges (SCEs), chromosome aberrations (CAs) and micronuclei (MN) as biomarkers in peripheral lymphocytes of 26 volunteers (14 workers, 12 controls). The CA, SCE and MN frequency of offset printing workers was significantly higher than in their controls. The replication index (RI) was not affected while the mitotic index (MI) was affected most in the workers. It can be concluded from this study that chronic occupational exposure to printing dyes and thinner may lead to a slightly increased risk of genetic damage among offset printing workers. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：10 / 15

页数：6

共 38 条

[31] ON THE MECHANISM OF DIFFERENTIAL GIEMSA STAINING OF BROMODEOXYURIDINE-SUBSTITUTED CHROMOSOMES .2. DIFFERENCES BETWEEN THE DEMONSTRATION OF SISTER CHROMATID DIFFERENTIATION AND REPLICATION PATTERNS [J].