Serum paraoxonase 1 activity and lipid peroxidation levels in patients with age-related macular degeneration

被引:48
作者
Baskol, G [1 ]
Karakucuk, S
Oner, AO
Baskol, M
Kocer, D
Mirza, E
Saraymen, R
Üstdal, M
机构
[1] Erciyes Univ, Fac Med, Dept Biochem & Clin Biochem, Kayseri, Turkey
[2] Erciyes Univ, Fac Med, Dept Ophthalmol, Kayseri, Turkey
[3] Erciyes Univ, Fac Med, Dept Internal Med, Kayseri, Turkey
关键词
age-related macular degeneration; paraoxonase; 1; malondialdehyde;
D O I
10.1159/000089269
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Our objective was to investigate antioxidant paraoxonase 1 (PON1) activity together with malondialdehyde (MDA) levels to evaluate oxidative stress in patients with age-related macular degeneration (AMD), an important cause of blindness in the elderly population. Serum PON1 activity and MDA levels were analyzed in 37 patients with AMD and compared with 29 healthy controls using a spectrophotometric method. Serum MDA levels were significantly higher in the patient group (2.76 +/- 1.28 nmol/ml) than controls (1.00 +/- 0.36 nmol/ml; p < 0.001), whereas PON1 activity was lower in the patient group (132.27 +/- 63.39 U/I) than controls (312.13 +/- 136.23 U/I; p < 0.001). There was a negative correlation between MDA and PON1 levels (r = - 0.470, p < 0.001). We conclude that the observed increase in MDA levels may be related to decreased PON1 activity; the present data also demonstrated that an obvious negative correlation between PON1 activity and MDA levels exists in patients with AMD. PON1 is also an antioxidant agent, therefore effective antioxidant therapy to inhibit lipid peroxidation is necessary and agents to increase PON1 activity may be a therapeutic option in AMD. Copyright (c) 2006 S. Karger AG, Basel.
引用
收藏
页码:12 / 16
页数:5
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