Comparative analysis of protein primary sequences with graph energy

被引:27
作者
Wu, Haiyan [1 ]
Zhang, Yusen [1 ]
Chen, Wei [1 ]
Mu, Zengchao [1 ]
机构
[1] Shandong Univ Weihai, Sch Math & Stat, Weihai 264209, Peoples R China
关键词
The graph energy; Laplacian energy; 2-D graphical representation; The increment of graphical energy; Similarity; LAPLACIAN ENERGY; REPRESENTATION; SIMILARITY/DISSIMILARITY; SIMILARITY; DESCRIPTOR; EVOLUTION;
D O I
10.1016/j.physa.2015.04.017
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We propose in this paper, the graph energy and Laplacian energy of 20 amino acids based on the codons coding the amino acids and apply them to put forward a novel 2-D graphical representation of proteins. The novel graphical representation has no circuit or degeneracy, uniquely represents proteins and allows one to easily and quickly visually observe and inspect similarity/dissimilarity between them. It also leads to two novel protein descriptors, the graph energy of a protein sequence, and the increment of graph energy between two protein sequences. We develop similarities/dissimilarities model and successfully analyze the similarities/dissimilarities of ND5, 36PDs, 24TFs and 27AFPs with good results consistent with ClustalW even better ones. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:249 / 262
页数:14
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