Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran

被引:10
作者
Hashemi, Seyed Mehdi [1 ,2 ]
Ramroodi, Nourollah [3 ]
Fard, Hamed Amiri [3 ]
Talebian, Sahar [4 ]
Rohani, Maryam Haghighi [5 ]
Rezaei, Mahnaz [6 ]
Noora, Mehrangiz [6 ]
Salimi, Saeedeh [6 ,7 ]
机构
[1] Zahedan Univ Med Sci, Ali Ebne Abitaleb Hosp, Clin Immunol Res Ctr, Zahedan 9816743111, Iran
[2] Zahedan Univ Med Sci, Sch Med, Dept Internal Med, Zahedan 9816743111, Iran
[3] Zahedan Univ Med Sci, Sch Med, Dept Neurol, Zahedan 9816743111, Iran
[4] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad 9138813944, Iran
[5] Zahedan Univ Med Sci, Sch Med, Zahedan 9816743175, Iran
[6] Zahedan Univ Med Sci, Sch Med, Dept Clin Biochem, Zahedan 9816743175, Iran
[7] Zahedan Univ Med Sci, Cellular & Mol Res Ctr, Zahedan 9816743111, Iran
来源
MEDICINA-LITHUANIA | 2019年 / 55卷 / 02期
关键词
ischemic stroke; Factor V; MTHFR; prothrombin; polymorphism; METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR; C677T POLYMORPHISM; GLOBAL BURDEN; RISK; HOMOCYSTEINE; ASSOCIATION; METAANALYSIS; EPIDEMIOLOGY; FOLATE;
D O I
10.3390/medicina55020047
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objective: Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of MTHFR as well as FV genes on ischemic stroke. Materials and Methods: In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for MTHFR C677T, A1298C, C2572A and C4869G, FVL, and prothrombin G20210A polymorphisms. Results: The MTHFR 677CT genotype was more frequent in patients and increased risk of IS with Odds Ratio = 1.9. The MTHFR A1298C and C2572A polymorphisms were not associated with IS in dominant and recessive models. Our findings showed a significant decrease in the MTHFR 4869CG genotype in IS patients, and this variant was associated with a decreased risk of IS in the dominant model. The CAAT haplotype was associated with increased risk, and the GAAC haplotype was associated with decreased risk of IS compared to other haplotypes. There was no relation between FVL G1691A polymorphism and IS risk. Conclusions: The present study showed that the MTHFR 677CT genotype was more frequent and the MTHFR 4869CG genotype was less frequent in young IS patients.
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页数:10
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