Mature Pseudomonas aeruginosa Biofilms Prevail Compared to Young Biofilms in the Presence of Ceftazidime

被引：40

作者：

Bowler, Laura L. ^{[1
,2
]}

Zhanel, George G. ^{[2
]}

Ball, T. Blake ^{[2
,3
,4
]}

Saward, Laura L. ^{[1
,2
]}

机构：

[1] Cangene Corp, Res & Dev, Winnipeg, MB, Canada

[2] Univ Manitoba, Fac Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada

[3] Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, Winnipeg, MB, Canada

[4] Univ Manitoba, Fac Med, Dept Immunol, Winnipeg, MB R3E 0W3, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 09期

关键词：

BETA-LACTAMASE; ANTIBIOTIC-RESISTANCE; ESCHERICHIA-COLI; CYSTIC-FIBROSIS; EXPRESSION; MEROPENEM;

D O I：

10.1128/AAC.00650-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phenotypic tolerances to antibiotics of mature and young Pseudomonas aeruginosa PAO1 biofilms and released planktonic bacteria were compared for four antibiotics. Resistance levels were similar for gentamicin and ciprofloxacin but differed for ceftazidime and meropenem. beta-Lactamase mapping showed that, after 5 h of ceftazidime exposure, mature biofilms produced more beta-lactamase than young biofilms, facilitating the growth of released planktonic bacteria. This shows the importance of early treatment and choice of antibiotics for P. aeruginosa biofilm infections.

引用

页码：4976 / 4979

页数：4

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