Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

被引：55

作者：

Singh, Okram Mukherjee ^{[1
]}

Singh, Sarangthem Joychandra ^{[1
]}

Devi, Mutum Babita ^{[2
]}

Devi, Laitonjam Nalini ^{[2
]}

Singh, Nameirakpam Irabanta ^{[2
]}

Lee, Sang-Gyeong ^{[3
,4
]}

机构：

[1] Manipur Univ, Dept Chem, Imphal 795003, Manipur, India

[2] Manipur Univ, Dept Life Sci, Aerobiol Microbiol & Plant Pathol Lab, Imphal 795003, Manipur, India

[3] Gyeongsang Natl Univ, Dept Chem, Jinju 660701, GyeongNam, South Korea

[4] Gyeongsang Natl Univ, Res Inst Life Sci, Jinju 660701, GyeongNam, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 24期

关键词：

Dihydropyrimidine; Solvent-free; Antifungal activity;

D O I：

10.1016/j.bmcl.2008.10.063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger. (C) 2008 Published by Elsevier Ltd.

引用

页码：6462 / 6467

页数：6

共 32 条

[21] Cu(OTf)2:: a reusable catalyst for high-yield synthesis of 3,4-dihydropyrimidin-2(1H)-ones [J].

Paraskar, AS ;

Dewkar, GK ;

Sudalai, A .

TETRAHEDRON LETTERS, 2003, 44 (16) :3305-3308

[22] CALCIUM-ENTRY BLOCKERS AND ACTIVATORS - CONFORMATIONAL AND STRUCTURAL DETERMINANTS OF DIHYDROPYRIMIDINE CALCIUM-CHANNEL MODULATORS [J].

ROVNYAK, GC ;

KIMBALL, SD ;

BEYER, B ;

CUCINOTTA, G ;

DIMARCO, JD ;

GOUGOUTAS, J ;

HEDBERG, A ;

MALLEY, M ;

MCCARTHY, JP ;

ZHANG, RA ;

MORELAND, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (01) :119-129

[23] SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 3,4-DIHYDRO-6-METHYL-5-N-METHYL-CARBAMOYL-4-(SUBSTITUTED PHENYL)-2(1H)PYRIMIDINONES AND PYRIMIDINETHIONES [J].

SADANANDAM, YS ;

SHETTY, MM ;

DIWAN, PV .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (01) :87-92

[24] Cupric chloride promoted regioselective C-allylation of enaminones [J].

Singh, Sarangthem Joychandra ;

Singh, Okram Mukherjee .

TETRAHEDRON LETTERS, 2008, 49 (25) :3991-3994

[25] One-pot synthesis of dihydropyrimidiones catalyzed by strontium(II) triflate under solvent-free conditions [J].

Su, W ;

Li, JJ ;

Zheng, ZG ;

Shen, YC .

TETRAHEDRON LETTERS, 2005, 46 (36) :6037-6040

[26] A highly efficient solvent-free synthesis of dihydropyrimidinones catalyzed by zinc chloride [J].

Sun, Q ;

Wang, YQ ;

Ge, ZM ;

Cheng, TM ;

Li, RT .

SYNTHESIS-STUTTGART, 2004, (07) :1047-1051

[27] Intraspecific variability of Paecilomyces fumosoroseus: Effect of temperature on vegetative growth [J].

Vidal, C ;

Fargues, J ;

Lacey, LA .

JOURNAL OF INVERTEBRATE PATHOLOGY, 1997, 70 (01) :18-26

[28]

VINCENT JM, 1947, NATURE, V96, P596

[29] A SOLID-PHASE PROTOCOL OF THE BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS SUITABLE FOR COMBINATORIAL CHEMISTRY [J].

WIPF, P ;

CUNNINGHAM, A .

TETRAHEDRON LETTERS, 1995, 36 (43) :7819-7822

[30] Pathogenicity of the entomopathogenic fungi Paecilomyces spp. and Beauveria bassiana against the silverleaf whitefly, Bemisia argentifolii [J].

Wraight, SP ;

Carruthers, RI ;

Bradley, CA ;

Jaronski, ST ;

Lacey, LA ;

Wood, P ;

Galaini-Wraight, S .

JOURNAL OF INVERTEBRATE PATHOLOGY, 1998, 71 (03) :217-226

← 1 2 3 4 →