Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

被引：55

作者：

Singh, Okram Mukherjee ^{[1
]}

Singh, Sarangthem Joychandra ^{[1
]}

Devi, Mutum Babita ^{[2
]}

Devi, Laitonjam Nalini ^{[2
]}

Singh, Nameirakpam Irabanta ^{[2
]}

Lee, Sang-Gyeong ^{[3
,4
]}

机构：

[1] Manipur Univ, Dept Chem, Imphal 795003, Manipur, India

[2] Manipur Univ, Dept Life Sci, Aerobiol Microbiol & Plant Pathol Lab, Imphal 795003, Manipur, India

[3] Gyeongsang Natl Univ, Dept Chem, Jinju 660701, GyeongNam, South Korea

[4] Gyeongsang Natl Univ, Res Inst Life Sci, Jinju 660701, GyeongNam, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 24期

关键词：

Dihydropyrimidine; Solvent-free; Antifungal activity;

D O I：

10.1016/j.bmcl.2008.10.063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger. (C) 2008 Published by Elsevier Ltd.

引用

页码：6462 / 6467

页数：6

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