The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project

被引：14

作者：

Blokland, Gabriella A. M. ^{[1
,2
,3
,4
,27
]}

del Re, Elisabetta C. ^{[3
,5
,6
]}

Mesholam-Gately, Raquelle I. ^{[3
,7
]}

Jovicich, Jorge ^{[8
]}

Trampush, Joeyw. ^{[9
,10
,11
,12
,13
]}

Keshavan, Matcheri S. ^{[3
,7
,14
]}

DeLisi, Lynn E. ^{[3
,5
]}

Walters, James T. R. ^{[15
]}

Turner, Jessica A. ^{[16
,17
,18
]}

Malhotra, Anil K. ^{[9
,10
,11
,12
]}

Lencz, Todd ^{[9
,10
,11
,12
]}

Shenton, Martha E. ^{[3
,5
,6
]}

Voineskos, Aristotle N. ^{[15
]}

Rujescu, Dan ^{[16
,17
,18
]}

Giegling, Ina ^{[21
]}

Kahnv, Rene S. ^{[22
]}

Roffman, Joshua L. ^{[2
,3
,23
]}

Holt, Daphne J. ^{[2
,3
,23
]}

Ehrlich, Stefan ^{[3
,23
,24
]}

Kikinis, Zora ^{[3
,6
]}

Dazzan, Paola ^{[25
,26
]}

Murray, Robin M. ^{[25
,26
]}

Di Forti, Marta ^{[25
,26
]}

Lee, Jimmy ^{[27
]}

Sim, Kang

Lam, Max

Wolthusen, Rick P. F. ^{[3
,23
,24
]}

de Zwarte, Sonja M. C. ^{[22
]}

Walton, Esther ^{[22
]}

Cosgrove, Donna ^{[28
]}

Kelly, Sinead ^{[29
,30
]}

Maleki, Nasim ^{[2
,3
,23
]}

Osiecki, Lisa ^{[1
,27
]}

Picchioni, Marco M. ^{[25
,26
]}

Bramon, Elvira ^{[25
,26
,31
]}

Russo, Manuela ^{[25
,26
]}

David, Anthony S. ^{[25
,26
]}

Mondelli, Valeria ^{[25
,26
]}

Reinders, Antje A. T. S. ^{[25
,26
]}

Falcone, M. Aurora ^{[25
,26
]}

Hartmann, Annette M. ^{[21
]}

Konte, Bettina ^{[21
]}

Morris, Derek W. ^{[32
,33
]}

Gill, Michael ^{[29
]}

Corvin, Aiden P. ^{[29
]}

Cahn, Wiepke ^{[22
]}

Ho, New Fei

Liu, Jian Jun ^{[34
]}

Keefe, Richard S. E. ^{[35
]}

Gollub, Randy L. ^{[2
,3
,23
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Genom Med, Psychiat & Neurodev Genet Unit, 185 Cambridge St, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[3] Harvard Med Sch, Dept Psychiat, Boston, MA USA

[4] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA

[5] Vet Affairs Boston Healthcare Syst, Dept Psychiat, Brockton, MA USA

[6] Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA

[7] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA

[8] Univ Trento, Ctr Mind Brain Sci CiMEC, Trento, Italy

[9] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Div Northwell Hlth, Manhasset, NY USA

[10] Zucker Hillside Hosp, Div Northwell Hlth, Div Psychiat Res, Glen Oaks, NY USA

[11] Hofstra Northwell Sch Med, Dept Psychiat, Hempstead, NY USA

[12] Hofstra Northwell Sch Med, Dept Mol Med, Hempstead, NY USA

[13] BrainWorkup LLC, Los Angeles, CA USA

[14] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[15] Cardiff Univ, Dept Psychol Med, Cardiff, Wales

[16] Mind Res Network, Albuquerque, NM USA

[17] Georgia State Univ, Dept Psychol, Atlanta, GA 30303 USA

[18] Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA

[19] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA USA

[20] Univ Toronto, Campbell Family Mental Hlth Inst, Ctr Addict & Mental Hlth, Res Imaging Ctr,Fac Med,Dept Psychiat,Kimel Famil, Toronto, ON, Canada

[21] Univ Halle Wittenberg, Dept Psychiat Psychotherapy & Psychosomat, Halle, An Der Saale, Germany

[22] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands

[23] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, MGH HST, Charlestown, MA USA

[24] Tech Univ Dresden, Fac Med, Div Psychol & Social Med & Dev Neurosci, Dresden, Germany

[25] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[26] South London & Maudsley NHS Fdn Trust, NIHR, Mental Hlth Biomed Res Ctr, London, England

[27] Woodbridge Hosp, Inst Mental Hlth, Singapore, Singapore

[28] Natl Univ Ireland, Dept Psychol, Cognit Genet & Cognit Therapy Grp, Galway, Ireland

[29] Trinity Coll Dublin, Inst Mol Med, Dept Psychiat, Neuropsychiatr Genet Res Grp, Dublin, Ireland

[30] Univ Southern Calif, Keck Sch Med, Lab NeuroImaging, Los Angeles, CA USA

[31] UCL, Mental Hlth Neurosci Res Dept, UCL Div Psychiat, London, England

[32] Natl Univ Ireland, Neuroimaging & Cognit Genom NICOG Ctr, Cognit Genet & Cognit Therapy Grp, Galway, Ireland

[33] Natl Univ Ireland, Sch Psychol & Discipline Biochem, NCBES Galway Neurosci Ctr, Galway, Ireland

[34] Genome Inst, Singapore, Singapore

[35] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA

[36] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA

[37] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[38] NYU, Langone Med Ctr, Nathan S Kline Inst Psychiat Res, Dept Psychiat, New York, NY USA

[39] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA

[40] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Womens Hlth, Boston, MA USA

[41] Univ Massachusetts, Lab Appl Neuropsychol, Boston, MA 02125 USA

[42] Brigham & Womens Hosp, Dept Psychiat, 75 Francis St, Boston, MA 02115 USA

[43] Icahn Sch Med Mt Sinai, Dept Psychiat, Div Psychiat Gen, New York, NY USA

[44] Icahn Sch Med Mt Sinai, Dept Genet, Div Psychiat Gen, New York, NY USA

[45] Icahn Sch Med Mt Sinai, Dept Genom Sci, Div Psychiat Gen, New York, NY USA

[46] Bilkent Univ, Dept Psychol, Ankara, Turkey

[47] Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China

来源：

SCHIZOPHRENIA RESEARCH | 2018年 / 195卷

基金：

美国国家卫生研究院;

关键词：

Schizophrenia; Neuropsychology; Cognition; Neuroimaging; MRI; Genetics; GENOME-WIDE ASSOCIATION; SYNDROME SCALE PANSS; BIPOLAR DISORDER; YOUNG RELATIVES; POLYGENIC RISK; BRAIN VOLUMES; HERITABILITY; METAANALYSIS; LOCI; INTELLIGENCE;

D O I：

10.1016/j.schres.2017.09.024

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection. Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site. Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p < 1 x 10(-10)). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other. Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：306 / 317

页数：12

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