Nonenzymatic determination of glucose at near neutral pH values based on the use of nafion and platinum black coated microneedle electrode array

被引：86

作者：

Chinnadayyala, Somasekhar R. ^{[1
]}

Park, Ilhwan ^{[2
]}

Cho, Sungbo ^{[2
,3
]}

机构：

[1] Gachon Univ, Dept Biomed Engn, 191 Hambakmoe Ro, Incheon 21936, South Korea

[2] Gachon Univ, Gachon Adv Inst Hlth Sci & Technol, Incheon 21999, South Korea

[3] Gachon Univ, Dept Elect Engn, 1342 Seongnamdaero, Seongnam Si 13120, Gyeonggi Do, South Korea

来源：

MICROCHIMICA ACTA | 2018年 / 185卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Chloroplatinic acid hexahydrate; Lead acetate; Parylene; Polydimethylsiloxane; Electrochemical sensor; Scanning electron microscope; Chronoamperometry; Cyclic voltammetry; Electrodeposition; DRUG-DELIVERY; BIOSENSOR; ENZYME; NANOPARTICLES; FABRICATION; SENSOR;

D O I：

10.1007/s00604-018-2770-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The authors report on a microneedle-based amperometric nonenzymatic glucose sensor for painless and continuous monitoring of glucose. It consists of 3 x 5 sharp stainless steel microneedles micromachined from a stainless steel substrate. The microneedles are 600 and 100 mu m in height and width, respectively. Nafion and platinum black were sequentially coated onto the tip of gold-coated microneedles and used for nonenzymatic (direct) sensing of glucose. Attractive features of the modified microneedle electrode include (a) a low working potential (+0.12 V vs. Ag/AgCl), (b) a linear response in the physiologically relevant range (1-40 mM), (c) a sensitivity as high as 175 mu A mM(-1) cm(-2), (d) a 23 mu M detection limit, and (e) a response time of 2 s. The sensor also exhibits good reproducibility and stability. The sensor is selective for glucose even in the presence of 10-fold higher concentrations of ascorbic acid, lactic acid, dopamine, uric acid, and acetaminophen.

引用

页数：8

共 38 条

[31] A dually functional 4-aminophenylboronic acid dimer for voltammetric detection of hypochlorite, glucose and fructose [J].

Thiruppathi, Murugan ;

Thiyagarajan, Natarajan ;

Gopinathan, Manavalan ;

Chang, Jen-Lin ;

Zen, Jyh-Myng .

MICROCHIMICA ACTA, 2017, 184 (10) :4073-4080

[32]

Toghill KE, 2010, INT J ELECTROCHEM SC, V5, P1246

[33] Non-enzymatic electrochemical sensing of glucose [J].

Wang, Guangfeng ;

He, Xiuping ;

Wang, Lingling ;

Gu, Aixia ;

Huang, Yan ;

Fang, Bin ;

Geng, Baoyou ;

Zhang, Xiaojun .

MICROCHIMICA ACTA, 2013, 180 (3-4) :161-186

[34] Microneedle array-based carbon paste amperometric sensors and biosensors [J].

Windmiller, Joshua Ray ;

Zhou, Nandi ;

Chuang, Min-Chieh ;

Valdes-Ramirez, Gabriela ;

Santhosh, Padmanabhan ;

Miller, Philip R. ;

Narayan, Roger ;

Wang, Joseph .

ANALYST, 2011, 136 (09) :1846-1851

[35] Sensing glucose based on its affinity for concanavalin A on a glassy carbon electrode modified with a C60 fullerene nanocomposite [J].

Ye, Cui ;

Zhong, Xia ;

Chai, Yaqin ;

Yuan, Ruo .

MICROCHIMICA ACTA, 2015, 182 (13-14) :2215-2221

[36] Fabrication of a Microneedle/CNT Hierarchical Micro/Nano Surface Electrochemical Sensor and Its In-Vitro Glucose Sensing Characterization [J].

Yoon, Youngsam ;

Lee, Gil S. ;

Yoo, Koangki ;

Lee, Jeong-Bong .

SENSORS, 2013, 13 (12) :16672-16681

[37] Ultrasensitive non-enzymatic glucose sensing at near-neutral pH values via anodic stripping voltammetry using a glassy carbon electrode modified with Pt3Pd nanoparticles and reduced graphene oxide [J].

Zhao, Li ;

Wu, Genghuang ;

Cai, Zhixiong ;

Zhao, Tingting ;

Yao, Qiuhong ;

Chen, Xi .

MICROCHIMICA ACTA, 2015, 182 (11-12) :2055-2060

[38]

Zimmermann S, 2003, SOL STAT SENS ACT MI, P99, DOI [10.1109/SENSOR.2003.1215262, DOI 10.1109/SENS0R.2003.1215262]

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