Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review

被引：26

作者：

Dai, Xin ^{[1
]}

Bowatte, Gayan ^{[1
]}

Lowe, Adrian J. ^{[1
,2
]}

Matheson, Melanie C. ^{[1
]}

Gurrin, Lyle C. ^{[1
]}

Burgess, John A. ^{[1
]}

Dharmage, Shyamali C. ^{[1
,2
]}

Lodge, Caroline J. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Allergy & Lung Hlth Unit, Level 3 207 Bouverie St, Melbourne, Vic 3010, Australia

[2] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2018年 / 18卷 / 03期

基金：

英国医学研究理事会;

关键词：

Epidemiology; Genetics; Rhinitis; Asthma; Atopic dermatitis; Reviews; ENVIRONMENTAL TOBACCO-SMOKE; OXIDATIVE STRESS; MATERNAL SMOKING; PASSIVE SMOKING; REACTIVE OXYGEN; EXPOSURE; POLYMORPHISMS; GSTP1; VARIANTS; CHILDREN;

D O I：

10.1007/s11882-018-0771-0

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Glutathione S-transferase (GST) genes are involved in oxidative stress management and may modify the impact of indoor air pollution. We aimed to assess the influence of GST genes on the relationship between indoor air pollution and allergy/lung function. Our systematic review identified 22 eligible studies, with 15 supporting a gene-environment interaction. Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits. However, findings differed in terms of risk alleles and specific exposures. High-exposure heterogeneity precluded meta-analysis. We found evidence that respiratory effects of indoor air pollution depend on the individual's GST profile. This may help explain the inconsistent associations found when gene-environment interactions are not considered. Future studies should aim to improve the accuracy of pollution assessment and investigate this finding in different populations.

引用

页数：15

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