Matrix-assisted laser desorption ionization/time-of-flight mass spectrometry for clinical diagnosis

被引：38
作者：
Cho, Yi-Tzu [1 ]
Su, Hung [2 ]
Huang, Tiao-Lai [3 ,4 ]
Chen, Hung-Chun [5 ]
Wu, Wen-Jeng [6 ]
Wu, Pei-Chang [7 ]
Wu, Deng-Chyang [8 ]
Shiea, Jentaie [2 ,9 ]
机构：
[1] Yuh Ing Jr Coll Hlth Care & Management, Dept Cosmet Applicat & Management, Kaohsiung, Taiwan
[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan
[3] Kaohsiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung, Taiwan
[4] Chang Gung Univ, Coll Med, Guishan, Taiwan
[5] Kaohsiung Med Univ, Div Nephrol, Dept Med, Chung Ho Mem Hosp, Kaohsiung, Taiwan
[6] Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung, Taiwan
[7] Chang Gung Univ, Dept Ophthalmol, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Coll Med, Kaohsiung, Taiwan
[8] Kaohsiung Med Univ, Div Gastroenterol, Dept Internal Med, Kaohsiung, Taiwan
[9] Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung, Taiwan
来源：
CLINICA CHIMICA ACTA | 2013年 / 415卷
关键词：
Matrix-assisted laser desorption; ionization/time-of-flight mass spectrometry; Clinical diagnosis; Disease biomarkers; Multivariate analysis; Principle component analysis; MALDI-TOF-MS; HUMAN NEUTROPHIL PEPTIDES; SERUM-FREE HEMOGLOBIN; NONENZYMATIC GLYCATION; MULTIVARIATE-ANALYSIS; PROTEIN BIOMARKERS; SAMPLE PREPARATION; GLYCO-OXIDATION; BREAST-CANCER; HUMAN GLOBINS;
D O I：
10.1016/j.cca.2012.10.032
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: Matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry is known as an extremely sensitive analytical tool for characterizing different types of biological compounds including proteins, peptides and lipids. Since MALDI-TOF analysis requires very simple sample pretreatment, the technique can be used for rapidly detecting biochemical compounds serving as disease biomarkers. Results: This mini-review focuses on the applications of MALDI-TOF in the detection of potential disease biomarkers in various biological samples. Conclusions: The potential disease biomarkers are mostly abundant proteins, peptides, or lipids including: albumin; hemoglobin; alpha-defensins; trimethylamine; phospholipids; and glycated alpha- and beta-globin, which are indicators of albuminuria; fecal occult blood and ischemic stroke; dry eye disease and/or aging; trimethylaniuria; breast cancer; and diabetes, respectively. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：266 / 275
页数：10
相关论文
共 97 条
[1]   Impact of sample preparation in peptide/protein profiling in human serum by MALDI-TOF mass spectrometry [J].
Aresta, Antonella ;
Calvano, Cosima D. ;
Palmisano, Francesco ;
Zambonin, Carlo G. ;
Monaco, Alessandro ;
Tornmasi, Stefania ;
Pilato, Brunella ;
Paradiso, Angelo .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 46 (01) :157-164
[2]   MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications [J].
Balluff, Benjamin ;
Schoene, Cedrik ;
Hoefler, Heinz ;
Walch, Axel .
HISTOCHEMISTRY AND CELL BIOLOGY, 2011, 136 (03) :227-244
[3]   MALDI-TOF-MS analysis of protein and DNA [J].
Bonk, T ;
Humeny, A .
NEUROSCIENTIST, 2001, 7 (01) :6-12
[4]   Free hemoglobin -: A dangerous signal for the immune system in patients with carotid atherosclerosis? [J].
Buttari, Brigitta ;
Profumo, Elisabetta ;
Petrone, Linda ;
Pietraforte, Donatella ;
Siracusano, Alessandra ;
Margutti, Paola ;
Delunardo, Federica ;
Ortona, Elena ;
Mfnetti, Maurizio ;
Salvati, Bruno ;
Rigano, Rachele .
AUTOIMMUNITY, PT C: THE MOSAIC OF AUTOIMMUNITY, 2007, 1107 :42-50
[5]   Optimization of analytical and pre-analytical conditions for MALDI-TOF-MS human urine protein profiles [J].
Calvano, C. D. ;
Aresta, A. ;
Iacovone, M. ;
De Benedetto, G. E. ;
Zambonin, C. G. ;
Battaglia, M. ;
Ditonno, P. ;
Rutigliano, M. ;
Bettocchi, C. .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, 51 (04) :907-914
[6]   Hepcidin assay in serum by SELDI-TOF-MS and other approaches [J].
Castagna, Annalisa ;
Campostrini, Natascia ;
Zaninotto, Federica ;
Girelli, Domenico .
JOURNAL OF PROTEOMICS, 2010, 73 (03) :527-536
[7]   Analysis of the saliva from patients with oral cancer by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [J].
Chen, YC ;
Li, TY ;
Tsai, MF .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2002, 16 (05) :364-369
[8]  
Chiang Y.Y., 2011, TAIW SOC MASS SPECTR
[9]   The study of interferences for diagnosing albuminuria by matrix-assisted laser desorption ionization/time-of-flight mass spectrometry [J].
Cho, Yi-Tzu ;
Chen, Yu-Syuan ;
Hu, Jia-Lun ;
Shiea, Jentaie ;
Yeh, Shih Meng ;
Chen, Hung-Chun ;
Lee, Yi-Chern ;
Wu, Deng-Chyang .
CLINICA CHIMICA ACTA, 2012, 413 (9-10) :875-882
[10]   Serum Apolipoproteins C-I and C-III Are Reduced in Stomach Cancer Patients: Results from MALDI-Based Peptidome and Immuno-Based Clinical Assays [J].
Cohen, Meital ;
Yossef, Rami ;
Erez, Tamir ;
Kugel, Aleksandra ;
Welt, Michael ;
Karpasas, Mark M. ;
Bones, Jonathan ;
Rudd, Pauline M. ;
Taieb, Julien ;
Boissin, Herve ;
Harats, Dror ;
Noy, Karin ;
Tekoah, Yoram ;
Lichtenstein, Rachel G. ;
Rubin, Eitan ;
Porgador, Angel .
PLOS ONE, 2011, 6 (01)
12345678910